Publication list Prof. R.H. Müller
(Total
Publications: 1566)
Patents/Patent
applications:
21 (not listed)
Books:
20
Refereed papers:
339
Proceedings:
366
Abstracts:
704
(1) Müller, R. H.,
Colloidal Carriers for Controlled Drug Delivery and Targeting - Modification,
Characterization and in vivo Distribution, Wissenschaftliche
Verlagsgesellschaft Stuttgart, CRC Press Boca Raton, 379 S., 1991
(2) Müller, R. H., Zetapotential und Partikelladung in der Laborpraxis – Einführung in die Theorie, praktische Meßdurchführung, Dateninterpretation, Wissenschaftliche Verlagsgesellschaft Stuttgart, 254 S.,1996
(3) Müller, R. H., Schuhmann, R., Teilchengrößenmessung in der Laborpraxis, Wissenschaftliche Verlagsgesellschaft Stuttgart, 191 S., 1996
(4) Müller, R. H., Hildebrand, G. E. (Hrsg), Pharmazeutische Technologie: Moderne Arzneiformen, Lehrbuch für Studierende der Pharmazie - Nachschlagewerk für Apotheker in Offizin, Krankenhaus und Forschung, Wissenschaftliche Verlagsgesellschaft Stuttgart, 1. Aufl., 348 S., 1997
(5) Müller, R. H., Mehnert, W. (Hrsg), Particle and Surface Characterisation Methods, Wissenschaftliche Verlagsgesellschaft Stuttgart, 280 S., 1997
(6) Müller, R. H., Hildebrand, G. E. (Hrsg), Pharmazeutische Technologie: Moderne Arzneiformen, Lehrbuch für Studierende der Pharmazie - Nachschlagewerk für Apotheker in Offizin, Krankenhaus und Forschung, Wissenschaftliche Verlagsgesellschaft Stuttgart, 2. erweiterte Aufl., 471 S., 1998
(7) Diederichs, J. E., Müller, R. H. (Hrsg), Future Strategies for Drug Delivery with Particulate Systems, Wissenschaftliche Verlagsgesellschaft Stuttgart, 194 S., 1998
(8) Müller, R. H., Hildebrand, G. E., Jachowicz, R., Kubis, A., Klawe, J. (Hrsg), Technologia nowoczesnych postaci leków, Wydawnictwo Lekarskie PZWL Warschau, 356 S., 1998
(9) Müller, R. H.,
Benita, S., Böhm, B. (Hrsg), Emulsions and Nanosuspensions
for the Formulation of Poorly Soluble Drugs, medpharm Scientific
Publishers Stuttgart, 396 S., 1998
(10) Müller, R. H., Schneppe, T., Qualitätsmanagement und Validierung in der pharmazeutischen Praxis, Editio Cantor Verlag Aulendorf, 182 S., 1999
(11) Zabka, M., Müller, R. H., Hildebrand, G. E. (Hrsg), Moderné lieky vo farmaceutickej technológii, slovakische Übersetzung des Lehrbuchs „Pharmazeutische Technologie: Moderne Arzneiformen“, Slovak Academic Press Bratislava, 487 S., 1999
(12) Kayser, O., Müller, R. H. (Hrsg), Pharmazeutische Biotechnologie. Ein Kompendium für Forschung und Praxis, Wissenschaftliche Verlagsgesellschaft, Stuttgart, 2000
(13) Zabka, M., Müller, R. H., Hildebrand, G. E. (Hrsg), Moderní lékové formy ve farmaceutické technologii, tschechische Übersetzung des Lehrbuchs „Pharmazeutische Technologie: Moderne Arzneiformen“, Slovak Academic Press Bratislava, 486 S., 2001
(14) Müller, R. H., Böhm, B. (Hrsg), Dispersion Techniques for Laboratory and Industrial Scale Processing, Wissenschaftliche Verlagsgesellschaft Stuttgart, 113 S., 2001
(15) Müller, R. H., Schneppe, T., Qualitätsmanagement und Validierung in der pharmazeutischen Praxis, Editio Cantor Verlag Aulendorf, 2. erweiterte Aufl., 218 S., 2003
(16) Kayser, O., Müller, R. H. (Hrsg), Biotechnologia Farmaceutiyczna, polnische Übersetzung des Buches „Pharmazeutische Biotechnologie. Ein Kompendium für Forschung und Praxis“, Wydawnictwo Lekarskie PZWL Warschau, 415 S., 2003
(17) Kayser, O., Müller, R. H. (Hrsg),
Pharmaceutical Biotechnology. Drug Discovery and Clinical Applications, Wiley-VCH,
Weinheim, 311 S., 2004
(18) Müller, R. H., Hildebrand, G. E. (Hrsg), chinesische Übersetzung des Lehrbuches: Pharmazeutische Technologie: Moderne Arzneiformen, Lehrbuch für Studierende der Pharmazie - Nachschlagewerk für Apotheker in Offizin, Krankenhaus und Forschung, 2. erweiterte Aufl., People’s Military Medical Press, 341 S., 2004
(19) Keck, C.M., Müller, R. H., Moderne Pharmazeutische Technologie (Modern Pharmaceutics), Lehrbuch für Studierende der Pharmazie & Nachschlagewerk für Apotheker in Offizin und Forschung, www.pharmazie-lehrbuch.de, 2009
(20) Keck, C.M., Müller, R. H., Moderne Pharmazeutische Technologie (Modern Pharmaceutics), Lehrbuch für Studierende der Pharmazie & Nachschlagewerk für Apotheker in Offizin und Forschung, www.pharmazie-lehrbuch.de, 2. Aufl., 2012
(1) Müller, R. H., Polydispersität, elektrophoretische Beweglichkeit hochdisperser Systeme, PhD thesis, University of Kiel, Germany, 1983
(2) Davis, S. S.,
Douglas, S., Illum, L., Jones. P. D. E., Mak, E., Müller, R. H., "Targeting
of Colloidal Carriers and the Role of Surface Properties", in: Targeting
of Drugs with Synthetic Systems (Gregoriadis, G., Senior, J. und Poste, G., eds.) Plenum, 123, 1986
(3) Müller, R. H.,
Davis, S. S., Illum, L., Mak, E., "Particle Charge and Surface
Hydrophobicity of Colloidal Drug Carriers", in: Targeting of Drugs with
Synthetic Systems (Gregoriadis, G., Senior, J. und Poste, G., eds.) Plenum, 239 ,1986
(4) Müller, R. H.,
Heinemann, S., Surface Modelling of Microparticles as Parenteral Systems
with High Tissue Affinity, in: Bioadhesion - Possibilities and Future Trends
(Gurny, R. and Junginger, H. E., eds.), Wissenschaftliche Verlagsgesellschaft
Stuttgart, 202-214, 1989
(5) Müller, R. H.,
Davis, S. S., Mak, E., "Surface Characterization of Colloidal Drug
Carriers for Drug Targeting by Aqueous Two Phase Partitioning", in:
Separation using Aqueous Phase Systems: Applications in Cell Biology and
Biotechnology (Fisher, D. und Sutherland, I. A.,eds.) Plenum New
York, 149-155, 1989
(6) Müller, R. H.,
Heinemann, S., Blunk, T., Rudt, S., "PCS and
zeta potential characterization of model drug carriers - essential information
for the interpretation of in vitro and in vivo data", in: Laser Light
Scattering in Biochemistry (Sattelle, D. B. and Harding, S., eds.), Redwood
Press Ltd., Melksham, Wiltshire, 425-440, 1992
(7) Müller, R. H., Feste Lipidnanopartikel (SLN), in: Pharmazeutische Technologie: Moderne Arzneiformen (Müller, R. H., Hildebrand, G. E. Hrsg.), Wissenschaftliche Verlagsgesellschaft Stuttgart, 265-272, 1997
(8) Müller, R. H., „Nanosuspensionen - eine neue Formulierung für schwerlösliche Arzneistoffe“, in: Pharmazeutische Technologie: Moderne Arzneiformen (Müller, R. H., Hildebrand, G. E., Hrsg.), Wissenschaftliche Verlagsgesellschaft Stuttgart, 273-278, 1997
(9) Müller, R. H., „Surface Hydrophobicity - Determination by ROSE Bengal (RB) Adsorption Methods“, in: Particle and Surface Characterisation Methods (Müller, R. H., Mehnert, W., Hrsg), Wissenschaftliche Verlagsgesellschaft Stuttgart, 215-228, 1997
(10) Thode, K., Müller, R. H., „Theory and Set Up of Hydrophobic Interaction Cromatography (HIC)“, in: Particle and Surface Characterisation Methods (Müller, R. H., Mehnert, W., Hrsg), Wissenschaftliche Verlagsgesellschaft Stuttgart, 229-234, 1997
(11) Müller, R. H., „HIC for the Determination of Surface Hydrophobicity of Particulates“, in: Particle and Surface Characterisation Methods (Müller, R. H., Mehnert, W., Hrsg), Wissenschaftliche Verlagsgesellschaft Stuttgart, 235-249, 1997
(12) Thode, K., Kresse, M., Müller, R. H., „HIC of Iron Oxide Dispersions Stabilized by Different Macromolecules“, in: Particle and Surface Characterisation Methods (Müller, R. H., Mehnert, W., Hrsg), Wissenschaftliche Verlagsgesellschaft Stuttgart, 251-259, 1997
(13) Müller, R. H., Lück, M., Harnisch, S., Thode, K.,
„Intravenously Injected Particles; Surface Properties and Interaction with
Blood Proteins - the Key Determining the Organ Distribution“, in: Scientific
and Clinical Applications of Magnetic Carriers (Schütt, W., Teller, J., Häfeli,
U., Zborowski, M., eds.), 135-148, 1997
(14) Müller, R. H., Solid Lipid Nanoparticles,
nanosuspensions and liposomes for pharmaceutical and cosmetic applications, in:
Future Strategies for Drug Delivery with Particulate Systems (Diederichs, J.E.
and Müller, R.H., eds.), CRC Press Boca Raton, 71-72, 1998
(15) Müller, R. H., Particulate
systems for the controlled delivery of active compounds in pharmaceutics and
cosmetics, in: Future Strategies for Drug Delivery with Particulate Systems
(Diederichs, J.E. and Müller, R.H., eds.), CRC Press Boca Raton, 73-90, 1998
(16) Runge, S. A., Müller, R. H.,
Solid lipid nanoparticles (SLN™) for oral administration - drug incorporation
and degradation, in: Future Strategies for Drug Delivery with Particulate
Systems (Diederichs, J.E. and Müller, R.H., eds.), CRC Press Boca Raton,
91-100, 1998
(17) Peters, K., Müller, R. H.,
Nanosuspensions - a novel formulation of poorly soluble drugs, in: Future
Strategies for Drug Delivery with Particulate Systems (Diederichs, J.E. and
Müller, R.H., eds.), CRC Press Boca Raton, 101-108, 1998
(18) Lück, M., Paulke, B.-P., Schröder, W., Müller, R. H.,Two-dimensional
electrophoresis (2-DE) for the determination of plasma proteins adsorbed on
model drug carriers, in: Future Strategies for Drug Delivery with Particulate
Systems (Diederichs, J. E. and Müller, R. H., eds.), CRC Press Boca Raton,
109-117, 1998
(19) Herbort, J., Diederichs, J. E., Müller, R. H.,
Development of a liposomal formulation for hair care use, in: Future Strategies
for Drug Delivery with Particulate Systems (Diederichs, J. E. and Müller, R.
H., eds.), CRC Press Boca Raton, 118-126, 1998
(20) Müller, R H., Runge, S. A. „Solid Lipid
Nanoparticles (SLNÒ)
for controlled drug delivery“, in: Submicron Emulsions in Drug Targeting and
Delivery (Benita, S., ed.), 219-234, 1998
(21) Müller, R. H., Böhm, B. H. L.,
Nanosuspensions, in: Emulsions and Nanosuspensions for the Formulation of
Poorly Soluble Drugs (Müller, R. H., Benita, S., Böhm, B. H. L., eds.),
medpharm Scientific Publishers Stuttgart, 149-174, 1998
(22) Müller, R. H., Feste Lipidnanopartikel (SLN), in: Pharmazeutische Technologie: Moderne Arzneiformen (Müller, R. H., Hildebrand, G. E. Hrsg.), 2. Auflage, Wissenschaftliche Verlagsgesellschaft Stuttgart, 357-366, 1998
(23) Müller, R. H., Alkoholische Pflanzenextrakte, in: Pharmazeutische Technologie: Moderne Arzneiformen (Müller, R. H., Hildebrand, G. E. Hrsg.), 2. Auflage, Wissenschaftliche Verlagsgesellschaft Stuttgart, 119-120, 1998
(24) Müller, R. H., „Nanosuspensionen - eine neue Formulierung für schwerlösliche Arzneistoffe“, in: Pharmazeutische Technologie: Moderne Arzneiformen (Müller, R. H., Hildebrand, G. E., Hrsg.), 2. Auflage, Wissenschaftliche Verlagsgesellschaft Stuttgart, 393-400, 1998
(25) Müller, R. H., Nanorozproszenia jako nowe postacie leku dla trudno rozpuszczalnych substancji leczniczych, in: Kubis, A., Jachowicz, R., Müller, R. H., Hildebrand, G. E., Technologia nowoczesnych postaci leków, Wydawnictwo Lekarskie PZWL, Warschau, 300-306, 1998
(26) Gref, R., Quellec, P., Alonso, M. J., Tobio, M., Lück,
M., Müller, R. H., Dellacherie, E., PEG-Coated
Nanospheres: Surface Optimization and Therapeutic Applications, in: Targeting
of Drugs: Strategies for Stealth Therapeutic Systems, (Gregoriadis, G., ed.),
Kluwer Academic Pub, 275-286, 1998
(30) Müller, R. H., Jacobs, C., Kayser, O.,
Nanosuspensions for the Formulation of Poorly Soluble Drugs, in: Pharmaceutical
Emulsions and Suspensions (Nielloud, F. and Marti-Mestres, G., eds.), Marcel
Dekker, 383-407, 2000
(31) Müller, R. H., Olbrich, C., Neue Adjuvantien in der Impfstofftechnologie, in: Pharmazeutische Biotechnologie (Kayser, O., Müller, R. H., eds.), Wissenschaftliche Verlagsgesellschaft, 283-302, 2000
(32) Müller, R. H., Böhm, B. H. L., Grau, M. J.,
Nanosuspensions - a formulation approach for poorly soluble and poorly
bioavailable drugs, in: Handbook of Pharmaceutical Controlled Release
Technology (Wise, D., ed.), 345-357, 2000
(33) Müller, R. H., Dingler, A., Schneppe, T., Gohla, S.,
Large scale production of solid lipid nanoparticles (SLNTM) and
nanosuspensions (DissoCubesTM), in: Handbook of Pharmaceutical
Controlled Release Technology (Wise, D., ed.),
359-376, 2000
(34) Müller, R. H., Lippacher, A., Gohla, S.,
Solid Lipid Nanoparticles (SLNâ)
as Carrier System for the Controlled Release of Drugs, in: Handbook of
Pharmaceutical Controlled Release Technology (Wise, D., ed.),
377-391, 2000
(35) Müller, R. H., Wissing, S. A.,
Solid lipid nanoparticles (SLN®, Lipopearls®) for
controlled delivery of active compounds, STP Pharma Sciences, Minutes Book
(36) Müller, R. H., Karsubke, G., Lemke, A.,
Nanosuspension system for oral delivery of poorly soluble drugs, 11th
Conference book of DMV Symposion on solid dosage formulation, DMV Japan, 26-25,
2002
(37) Müller, R. H., Radtke, M., Wissing, S.,
Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in
cosmetic and dermatological preparations, in: Human Skin, the Medium of Touch,
Bulletin Technique Gattefossé 2002, 131-152, 2002
(38) Müller, R. H., Wissing, S. A.,
SLN and Lipopearls for topical delivery of active compounds and contolled
release, in: Modified-Release Drug Delivery Systems (Rathbone, M. J., Hadgraft,
J., Roberts, M. S., eds.), Marcel Dekker,
571-587, 2003
(39) Müller, R. H., Jacobs, C., Kayser, O., DissoCubes
– a novel formulation for poorly soluble and poorly bioavailable drugs, in:
Modified-Release Drug Delivery Systems (Rathbone, M. J., Hadgraft, J., Roberts,
M. S., eds.), Marcel Dekker, 135-149, 2003
(40) Müller, R. H., Lipid-Nanopartikel (SLN, NLC) zur Verkapselung von kosmetischen Wirkstoffen, in: Kosmetikjahrbuch 2003, Global Ingredient & Formulation Guide, Verlag für chemische Industrie, Augsburg, 481-484, 2003
(41) Müller, R. H., Akkar, A., Drug
nanocrystals of poorly soluble drugs, in: Encyclopedia of Nanoscience and
Nanotechnology (H. S. Nalwa, ed.), American Scientific Publishers, 627-638,
2004
(42) Müller, R. H., Radtke, M., Wissing, S. A.,
Solid Lipid Nanoparticles and Nanostructured Lipid Carriers, in: Encyclopedia
of Nanoscience and Nanotechnology (H. S. Nalwa, ed.), American Scientific
Publishers, 43-56, 2004
(43) Wissing, S., Müller, R. H.,
Cosmetic applications of solid lipid nanoparticles (SLN) and nanostructured
lipid carriers (NLC), in: Textbook of Cosmetic Dermatology, 3rd Edition (Baran,
R., Mailbach, H. I., eds.), Taylor & Francis,
71-76, 2004
(44) Kayser, O., Müller, R. H., A primer on
Pharmaceutical Biotechnology and industrial applications, in: Pharmaceutical
Biotechnology (O. Kayser, R. H. Müller, eds.),
Wiley-VCH, 3-8, 2004
(45) Olbrich, C., Tabatt, K., Wissing, S. A., Schöler, N.,
Müller, R. H., Solid Lipid Nanoparticles:
Interaction with cells, cytokine production and enzymatic degradation, in:
Lipospheres in Drug Targets and Delivery: Approaches, Methods and Applications
(C. Nastruzzi, ed.), Routledge, 101-125, 2004
(46) Müller, R. H., Mehnert, W., Souto, E. B., Solid
lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) for dermal
delivery, in: Percutaneous Absorption: Drugs, Cosmetics, Mechanisms, Methods, 4th
Edition (R. L. Bronaugh, H. I. Maibach, eds.), Marcel Dekker, 719-738, 2005
(47) Müller, R. H., Möschwitzer, J., Bushrab, F. N.,
Manufacturing of nanoparticles by milling and homogenisation techniques, in:
Nanoparticle Technology for Drug Delivery (Gupta, Kompella, eds.), Marcel
Dekker, 21-51, 2006
(48) Müller, R. H., Junghanns, J.-U.,
Drug nanocrystals/nanosuspensions for the delivery of poorly soluble drugs, in:
Nanoparticulates as Drug Carriers (V. P. Torchilin, ed.), Imperial College
Press, 307-328, 2006
(49) Müller, R. H., Souto, E. B., Göppert, T., Gohla, S.,
Production of biofunctionalized solid lipid nanoparticles (SLN) for
site-specific drug delivery, in: Nanotechnologies for the Life Science:
Biological and Pharmaceutical Materials (C. Kumar, ed.), Wiley-VCH,
287-303, 2006
(50) Müller, R. H., Göppert, T. M.,
Protein adsorption patterns on parenteral lipid formulations – key factor
determining the in vivo fate, in: Role of Lipid Excipients in Modifying Oral
and Parenteral Drug Delivery: Basic Principles and Biological Examples (Kishor
M. Wasan, ed.), Wiley-VCH, 124-159, 2006
(51) Souto, E. B., Müller, R. H.,
Lipid nanoparticles (SLN and NLC) for drug delivery, in: Nanoparticles for
pharmaceutical applications (A. Domb, Y Tobata, R. Kumar, S. Farber, eds.),
American Scientific Publishers, 103-122, 2007
(52) Möschwitzer, J., Müller, R. H.,
Drug nanocrystals – the universal formulation approach for poorly soluble
drugs, in: Nanoparticulate Drug Delivery Systems: Recent Trends and Emerging
Technologies (D. Thassu, M. Deleers, Y. Pathak, eds.), Informa Healthcare, 2007
(53) Souto, E. B., Müller, R. H.,
Lipid nanoparticles (solid lipid nanoparticles and nanostructured lipid
carriers) for cosmetic, dermal and transdermal applications, in:
Nanoparticulate Drug Delivery Systems: Recent Trends and Emerging Technologies
(D. Thassu, M. Deleers, Y. Pathak, eds.), CRC Press, 213-233, 2007
(54) Müller, R. H., Keck, C. M.,
Improvement of delivery & solubility of poorly soluble drugs by
nanonisation, in: Konferenzdokumentation LTS Academy, 12-17, 4.-5. Oktober 2007
(55) Keck, C. M., Hommoss, A., Müller, R. H.,
Lipid nanoparticles (SLN, NLC, LDC) for the enhancement of oral absorption, in:
Modified Release Drug Delivery Technology Vol. 1 (2nd edition) (R.
B. Walker, J. Hadgraft, M. S. Roberts, M. E. Lane, eds.), Informa Healthcare,
269-286, 2008
(56) Souto, E. B., Petersen, R., Müller, R. H.,
Lipid nanoparticles with solid matrix for dermal delivery: solid lipid
nanoparticles and nanostructured lipid carriers, in: Modified Release Drug
Delivery Technology Vol. 1 (2nd edition) (M. J. Rathbone, J.
Hadgraft, M. S. Roberts, eds.), Informa Healthcare, 357-379, 2008
(57) Souto, E. B., Müller, R. H.,
Challenging cosmetics: Solid Lipid Nanoparticles (SLN) and Nanostructured Lipid
Carriers NLC), in: Science and Applications of Skin Delivery Systems (J.
Wiechers, A. Kozlowski, eds.), Allured Publishing, 227-250, 2008
(58) Souto, E. B., Müller, R. H.,
Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) – lipid
nanoparticles for medicals and pharmaceuticals, in: Encyclopedia of Nanoscience
and Nanotechnology, 2nd Edition (H. S. Nalwa, ed.), American
Scientific Publishers, 2009
(59) Souto, E. B., Teeranchaideekul, V., Boonme, P.,
Müller, R. H., Junyaprasert, V. B., Lipid-based
nanocarriers for cutaneous administration of pharmaceutics, in: Encyclopedia of
Nanoscience and Nanotechnology, 2nd Edition (H. S. Nalwa, ed.),
American Scientific Publishers, 2009
(60) Keck, C.M., Müller, R. H, Photonenkorrelationsspektroskopie, in: Moderne Pharmazeutische Technologie (C.M. Keck, R.H. Müller, eds.), 56-61, 2009
(61) Pardeike, J., Müller, R. H., Bestimmung der Hautfeuchtigkeit, Hautelastizität und des transepidermalen Wasserverlustes (TEWL), in: Moderne Pharmazeutische Technologie (C.M. Keck, R.H. Müller, eds.), 84-87, 2009
(62) Pardeike, J., Müller, R. H., HET-CAM Test, in: Moderne Pharmazeutische Technologie (C.M. Keck, R.H. Müller, eds.), 91-93, 2009
(63) Pardeike, J., Müller, R. H.,
Tape Stripping Test, in: Moderne Pharmazeutische Technologie (C.M. Keck,
R.H. Müller, eds.), 110-112, 2009
(64) Keck, C. M., Al Shaal, L., Müller, R. H.,
smartCrystals – review of the second generation of drug nanocrystals, in:
Handbook of Materials for Nanomedicine (V. Torchillin, M. M. Amiji, eds.), Pan
Stanford Series on Biomedical Nanotechnology, Pan Stanford Publishing, London,
555-580, 2010
(65) Souto, E. B., Müller, R. H.,
Lipid nanoparticles – effect on bioavailability and pharmacokinetic changes, in:
Handbook of Experimental Pharmacology, Handbook of Experimental Pharmacology
Vol 197: Drug Delivery, Springer Publishing House, 115-141, 2010
(66) Souto, E. B., Keck, C., Müller, R. H.,
Technology of lipid nanoparticles (SLN, NLC) as nanocarriers for skin
applications: properties, production & cosmetic formulations, in:
Cosmetics: Types, Allergies and Applications (L. M. Hayes, ed.), Nova
Scientific Publishers, Hauppauge, New York, USA, Chapter 3, 69-91, 2011
(67) Souto, E. B., Teeranachaideekul, V., Boonme, P.,
Müller, R. H., Lipid-based nanocarriers for cutaneous administration
of pharmaceutics, in: Encyclopedia of Nanoscience and Nanotechnology Vol. 15
(H. S. Nalwa, ed.), American Scientific Publishers, Valencia/USA, 479-491, 2011
(68) Souto, E. B., Müller, R. H.,
Solid lipid nanoparticles and nanostructured lipid carriers – lipid
nanoparticles for medicals and pharmaceuticals, in: Encyclopedia of Nanoscience
and Nanotechnology Vol. 23 (H. S. Nalwa, ed.), American Scientific Publishers,
Valencia/USA, 313-328, 2011
(69) Müller R.H., Shegokar R., Gohla, S., Keck, C.M.,
NanoCrystals: Production, cellular drug delivery and current and future
products, in: Intracellular Delivery, Fundamental Biomedical Technologies,
Vol.5 (Part 2) (A. Prokop, ed.), Springer Science+Business Media, 411-432 (doi:10.1007/978-94-007-1248-5_15), 2011
(70) Möschwitzer, J., Müller, R. H.,
Nanocrystal formulations for improved delivery of poorly soluble drugs, in:
Nanomedicines in Health and Disease (R. J. Hunter, V. R. Preedy, eds.) CRC Press, New York, USA, 79-99, 2011
(71) Keck, C. M., Kobierski, S., Mauludin, R., Müller, R. H.,
Novel top down technologies: Effective production of ultra-fine drug
nanocrystals, in: Drug Delivery Strategies for Poorly Water-Soluble Drugs (D.
Douroumis, A. Fahr, eds.) Wiley, 247-264, 2013
(72) Keck, C. M., Müller, R. H., Schäfer, K. H., Nanotaxis for
antioxidants to make them biologically active, in: Recent advances in redox
active plant and microbial products: From basic chemistry to widespread
applications in Medicine and Agriculture, Springer (C. Jacob, ed.), in press
(73) Müller, R. H. and Möschwitzer, J., Nanosuspensions for the
Formulation of Poorly Soluble Drugs, in: Pharmaceutical Emulsions and
Suspensions (Nielloud, F. and Marti-Mestres, G., eds.), 2nd edition,
Publisher: Marcel Dekker, submitted
(1) Müller, B. W.
und Müller, R. H., Particle Size Analysis of Latex Suspensions and
Microemulsions by Photon Correlation Spectroscopy, J. Pharm. Sci.
73 (7), 915-918, 1984
(2) Müller, B. W. und Müller, R. H., Particle Size Distributions and Particle Size Alterations in Microemulsions, J. Pharm. Sci. 73 (7), 919-922, 1984
(3) Müller, B. W., Merz, J. und Müller, R. H., Simultane Bestimmung von elektrophoretischer Beweglichkeit und Teilchengröße bei überlagerter Konvektion an Suspensionen und Emulsionen, Colloid & Polymer Sci. 263, 342-347, 1985
(4) Illum, L.,
Davis, S. S., Müller, R. H., Mak, E. und West, P., The organ
distribution and circulation time of intravenously injected colloidal carriers
sterically stabilized with a blockcopolymer - poloxamine 908, Life Sciences 40,
367-374, 1987
(5) Illum, L.,
Jacobsen, L. O., Müller, R. H., Mak, E. und Davis, S. S., Surface
Characteristics and the Interaction of Colloidal Particles with Mouse
Peritoneal Macrophages, Biomaterials 8, 113-117, 1987
(6) Koosha, F.,
Müller, R. H., Davis, S. S., Polyhydroxybutyrate as a Drug
Carrier, Critical Reviews in Therapeutic Drug Carrier Systems 6, (2), 117-130,
1989
(7) Koosha, F.,
Müller, R. H., Davis, S. S. und Davies, M. C., The Surface
Chemical Structure of Poly (ß-hydroxybutyrate) Microparticles Produced by
Solvent Evaporation Process, J. Contr. Rel. 9,
149-157, 1989
(8) Davis, S. S.,
Illum, L., Müller, R. H., Landry, F., Wright, J., Harper, G., The
Effect of Infused Fat Emulsions on Reticuloendothelial Function in the Rabbit,
Clinical Nutrition 9, 260-265, 1990
(9) Lucks, J. S.,
Müller, B. W., Müller, R. H., Inorganic Suspensions -
Interaction with Salts and Ionic Surfactants, Int. J. Pharm. 58,
229-235, 1990
(10) Müller, R. H., Lherm, C., Herbort, J., Couvreur, P., In
Vitro Model for the Degradation of Alkylcyanoacrylate Nanoparticles,
Biomaterials 11, 590-595, 1990
(11) Lucks, J. S., Müller, B. W., Müller, R. H., Polymeric and emulsion carriers - Interaction with antiflocculants and ionic surfactants, Int. J. Pharm. 63, 183-188, 1990
(12) Wallis, K. H., Müller, R. H., Stabilität von Poloxamer und
Poloxamine Coatingfilmen auf Polystyrol Nanopartikeln, Acta Pharm. Technol.
36 (3), 127-132, 1990
(13) Carstensen, H., Müller, B. W., Müller, R. H., Adsorption
of ethoxylated surfactants on nanoparticles. I.
Characterization by Hydrophobic Interaction Chromatography, Int. J. Pharm. 67,
29-37, 1991
(14) Müller, R. H., Lherm, C., Herbort, J., Couvreur, P., Propidium
Iodide Loaded Polyalkylcyanoacrylate Particles - Labelling Conditions and
Loading Capacity, Colloid & Polym. Sci. 269,
147-152, 1991
(15) Stampa, B., Lucks, J. S., Müller, B. W., Müller, R.
H., Electrophoretic properties of emulsions for parenteral
nutrition determined by laser light scattering and application of the amplitude
weighted phase structure function (AWPS), J. Coll. Interf. Sci.
143 (1), 188-194, 1991
(16) Lukowski, G., Müller, R. H., Müller, B. W., Dittgen,
M., Acrylic acid copolymer nanoparticles for drug
delivery. I: Characterization of the surface properties relevant
for in vivo organ distribution, Int. J. Pharm. 84, 23-31,
1992
(17) Müller, R. H., Heinemann, S., Fat
emulsions for parenteral nutrition I: Evaluation of microscopic and laser light
scattering methods for the determination of the physical stability, Clinical
Nutrition 11, 223-236, 1992
(18) Tröster, S. D., Wallis, K. H., Müller, R. H., Kreuter,
J., Correlation of the surface hydrophobicity of 14C-poly
(methyl methacrylate) nanoparticles to their body distribution, J. Control. Rel.
20, 247-260, 1992
(19) Müller, R. H., Wallis, K. H., Tröster, S. D., Kreuter,
J., In vitro characterization of poly (methyl
methacrylate) nanoparticles and correlation to their in vivo fate, J. Control. Rel.
20, 237-246, 1992
(20) Müller, R. H., Lherm, C., Herbort, J., Blunk, T.,
Couvreur, P., Alkylcyanoacrylate Drug Carriers I: Physicochemical
Characterization of Nanoparticles with Different Alkyl Chain Length, Int. J.
Pharm. 84, 1-11, 1992
(21) Lherm, C., Müller, R. H., Puisieux F., Couvreur, P., Alkylcyanoacrylate
Drug Carriers II: Cytotoxicity of Cyanoacrylate Nanoparticles with Different
Alkyl Chain Length, Int. J. Pharm. 84, 13-22, 1992
(22) Carstensen, H., Müller, R. H., Müller, B. W., Particle
size, surface hydrophobicity and interaction with serum of parenteral fat
emulsions and model drug carriers as parameters related to RES uptake, Clinical
Nutrition 11, 289-297, 1992
(23) Rudt, S., Müller, R. H., In vitro
phagocytosis assay of nano- and microparticles by chemiluminescence. I. Effect
of analytical parameters, particle size and particle concentration, J. Control.
Rel. 22, 263-272, 1992
(24) Lukowski, G., Müller, R. H., Müller, B. W., Dittgen,
M., Acrylic acid copolymer nanoparticles for drug
delivery. II: Characterization of nanoparticles surface-modified
by adsorption of ethoxylated surfactants, Colloid & Polym. Sci.
271, 100-105, 1993
(25) Müller, R. H., Wallis, K. H.,
Surface modification of i.v. injectable biodegradable nanoparticles with
poloxamer polymers and poloxamine 908, Int. J. Pharm. 89, 25-31, 1993
(26) Wesemeyer, H., Müller, B. W., Müller, R. H.,
Adsorption of ethoxylated surfactants on nanoparticles. II. Determination of
adsorption enthalpy by microcalorimetry, Int. J. Pharm. 89,
33-40, 1993
(27) Müller, R. H., Heinemann, S.,
Fat emulsions for parenteral nutrition II: Characterization and physical
long-term stability of Lipofundin MCT/LCT, Clinical Nutrition 12, 298-309, 1993
(28) Maaßen, S., Fattal, E., Müller, R. H., Couvreur, P.,
Cell cultures for the assessment of toxicity and uptake of polymeric
particulate drug carriers, S.T.P. Pharma Sciences 3 (1), 11-22, 1993
(29) Rudt, S., Müller, R. H., In vitro
phagocytosis assay of nano- and microparticles by chemiluminescence. II. Effect
of surface modification by coating of particles with poloxamer on the
phagocytic uptake, J. Control. Rel. 25, 51-59, 1993
(30) Rudt, S., Müller, R. H., In vitro
phagocytosis assay of nano- and microparticles by chemiluminescence. III.
Uptake of differently sized surface-modified particles, and its correlation to
particle properties and in vivo distribution, Eur. J. Pharm. Sci.
1, 31-39, 1993
(31) Rudt, S., Wesemeyer, H., Müller, R. H., In vitro phagocytosis assay of nano- and microparticles by
chemiluminescence. IV. Effect of surface modification by coating of particles
with poloxamine and Antarox CO on the phagocytic uptake, J. Control. Rel.
25, 123-132, 1993
(32) Rudt, S., Müller, R. H., In vitro
uptake of polystyrene latex particles and parenteral fat emulsions by human
granulocytes, Int. J. Pharm. 99, 1-6, 1993
(33) Blunk, T., Hochstrasser, D. F., Sanchez, J.-C.,
Müller, B. W., Müller, R. H., Colloidal Carriers for
Intravenous Drug Targeting: Plasma Protein Adsorption Patterns on
Surface-Modified Latex Particles Evaluated by Two-dimensional Polyacrylamide
Gel Electrophoresis, Electrophoresis 14, 1382-1387, 1993
(34) Schwarz, C., Mehnert, W., Lucks, J. S., Müller, R. H.,
Solid lipid nanoparticles (SLN) for controlled drug delivery. I. Production,
characterization and sterilization, J. Control. Rel. 30,
83-96, 1994
(35) Bock, T. K., Lucks, J. S., Kleinebudde P., Müller R.
H., Müller B. W., High Pressure Homogenisation of Parenteral Fat
Emulsions - Influence of Process Parameters on Emulsion Quality, Eur. J. Pharm.
Biopharm. 40 (3), 157-160, 1994
(36) Müller, R. H., Heinemann, S.,
Fat emulsions for parenteral nutrition III: Lipofundin MCT/LCT regimens for
total parenteral nutrition (TPN) with low electrolyte load, Int. J. Pharm. 101,
175-189, 1994
(37) Müller, R. H., Heinemann, S.,
Fat emulsions for parenteral nutrition IV: Lipofundin MCT/LCT regimens for
total parenteral nutrition (TPN) with high electrolyte load, Int. J. Pharm. 107,
121-132, 1994
(38) Paulke, B.-R., Möglich, P.-M., Knippel, E., Budde, A.,
Nitzsche, R., Müller, R. H., Electrophoretic 3D-mobility profiles of latex
particles with different surface groups, Langmuir 11, 70-74, 1995
(39) Gref, R., Domb, A., Quellec, P., Blunk, T., Müller, R.
H., Verbavatz, J. M., Langer, R., The controlled intravenous
delivery of drugs using PEG-coated sterically stabilized nanospheres, Adv. Drug
Deliv. Rev. 16, 215-233, 1995
(40) Müller, R. H., Mehnert, W., Lucks, J. S., Schwarz, C.,
zur Mühlen, A., Weyhers, H., Freitas, C., Rühl, D., Solid Lipid
Nanoparticles (SLN) - An Alternative Colloidal Carrier System for Controlled
Drug Delivery, Eur. J. Pharm. Biopharm. 41 (1), 62-69, 1995
(41) Blunk, T., Lück, M., Calvör, A., Hochstrasser, D. F.,
Sanchez, J.-C., Müller, B. W., Müller, R. H., Kinetics of
Plasma Protein Adsorption on Model Particles for Controlled Drug Delivery and
Drug Targeting, Eur. J. Pharm. Biopharm. 42 (4), 262-268, 1996
(42) Zingel, C., Sachse, A., Rößling, G. L., Müller, R. H.,
Lyophilization and Rehydration of Iopromide-Carrying Liposomes, Int. J. Pharm. 140,
13-24, 1996
(43) Hedemann, H., Lück, M., Blunk, T., Frokjaer, S.,
Müller, R. H., Fat emulsions based on structured lipids (1,3-specific triglycerides): An investigation of the in vitro
interaction with plasma protein, Clin. Nutr.
15, 175-178, 1996
(44) Müller, R. H., Maaßen, S., Weyhers, H., Specht, F.,
Lucks, J. S., Cytotoxicity of magnetite loaded polylactide,
polylactide/glycolide particles and solid lipid nanoparticles (SLN), Int. J.
Pharm. 138, 85-94, 1996
(45) Ehlers, S., Bucke, W., Leitzke, S., Fortmann, L.,
Smith, D., Hänsch, H., Hahn, H., Bancroft, G., Müller, R. H.,
Liposomal amikacin for treatment of M. avium infections in clinically
relevant experimental settings, Int. J. Med. Microbiol. Virol.
Parasitol. Infect. Dis. 284, 218-231, 1996
(46) Müller, R. H., Maaßen, S., Weyhers, H., Mehnert, W.,
Phagocytic uptake and cytotoxicity of solid lipid nanoparticles (SLN)
sterically stabilized with Poloxamine 908 and Poloxamer 407, J. Drug Targeting
4 (3), 161-170, 1996
(47) Müller, R. H., Rühl, D., Lück, M., Paulke, B.-R.,
Influence of fluorescent labelling of polystyrene particles on phagocytic
uptake, surface hydrophobicity and plasma protein adsorption, Pharm. Res.
14 (1), 18-24, 1997
(48) Diederichs, J. E., Müller R. H.,
Microviscosity Measurements: Theory and Application for Parenteral Fat
Emulsions, Pharm. Tech., Jan. 1997, 41-56, 1997
(49) Almeida, A. J., Runge, S., Müller, R. H.,
Peptide-loaded Solid Lipid Nanoparticles (SLN): Influence of production
parameters, Int. J. Pharm. 149, 255-265, 1997
(50) Müller, R. H., Maaßen, S., Schwarz, C., Mehnert, W.,
Solid Lipid Nanoparticles (SLN) formulation for human use: interaction with
human granulocytes, J. Contr. Rel. 47, 261-269, 1997
(51) Rühl. D., Schulze-Forster, K., Müller, R. H.,
Interaction of differentiated HL60 cells with Poloxamer and Poloxamine surface
modified model drug carriers, Eur. J. Pharm. Biopharm. 5,
147-153, 1996
(52) Müller, R. H., Rühl, D., Runge, S.,
Biodegradation of SLN as a Function of Lipase Incubation time, Int. J. Pharm. 144,
115-121,1997
(53) Müller, R. H., Rühl, D., Runge, S., Schulze-Forster,
K., Mehnert, W., Cytotoxicity of Solid Lipid Nanoparticles as a
Function of the Lipid Matrix and the Surfactant, Pharm. Res.
14 (4), 458-462, 1997
(54) Thode, K., Lück, M., Kresse, M., Semmler, W., Müller, R. H., Determination of Plasma Protein Adsorption on Magnetic Iron Oxides: Sample Preparation, Pharm. Res. 14 (7), 905-910, 1997
(55) Müller, R. H., Weyhers, H., zur Mühlen, A., Dingler, A., Mehnert, W., Solid Lipid Nanoparticles (SLN) - ein neuartiger Wirkstoff-Carrier für Kosmetika und Pharmazeutika, I. Systemeigenschaften, Herstellung und Scaling up, Pharm. Ind. 59 (5), 423-427, 1997
(56) Mehnert, W., zur Mühlen, A., Dingler, A., Weyhers, H., Müller, R. H., Solid Lipid Nanoparticles (SLN) - ein neuartiger Wirkstoff-Carrier für Kosmetika und Pharmazeutika, II. Wirkstoff-Inkorporation, Freisetzung und Sterilisierbarkeit, Pharm. Ind. 59 (6), 511-514, 1997
(57) Müller, R. H., Dingler, A., Weyhers, H., zur Mühlen, A., Mehnert, W., Solid Lipid Nanoparticles (SLN) - ein neuartiger Wirkstoff-Carrier für Kosmetika und Pharmazeutika, III. Langzeitstabilität, Gefrier- und Sprühtrocknung, Anwendung in Kosmetika und Pharmazeutika, Pharm. Ind. 59 (7), 614-619, 1997
(58) Müller, R. H. and Runge, S. A., Kontrolowane dawkowanie leku za pomoca koloidalnych nošników (Kontrollierte Arzneistoffapplikation mit kolloidalen Carriern), Roczniki Naukowe, 1997
(59) Lück, M., Schröder, W., Harnisch, S., Thode, K.,
Blunk, T., Paulke, B.-R., Kresse, M., Müller, R. H.,
Identification of plasma proteins facilitated by enrichment on particulate
surfaces: Analysis by two-dimensional electrophoresis and N-terminal
microsequencing, Electrophoresis 18, 2961-2967, 1997
(60) Lück, M., Paulke, B.-R., Schröder, W., Blunk, T.,
Müller, R. H., Analysis of plasma protein adsorption on polymeric
nanoparticles with different surface characteristics, J. Biomed. Mat. Res.,
478-485, 1997
(61) Bucke, W. E., Leitzke, S., Diederichs, J. E., Borner,
K., Hahn, H., Ehlers, Müller, R. H.,
Surface-modified amikacin-liposomes: Organ distribution and interaction with
plasma proteins, J. Drug Targ. 5 (2), 99-108, 1997
(62) Thode, K., Lück, M., Schröder, W., Kresse, M.,
Semmler, W., Müller, R. H., Influence of the sample preparation on plasma protein
adsorption onto macromolecule stabilized iron oxide particles and N-terminal
microsequencing of unknown proteins, J. Drug Targ. 5 (1), 35-43, 1997
(63) Müller, R .H., Peters, K., Nanosuspensions for the formulation of poorly soluble drugs. I. Preparation by a size-reduction technique, Int. J. Pharm. 160, 229-237, 1998
(64) Schuhmann, R., Müller, R. H., Optimierung der Probenaufbereitung
für Coulter-Counter-Messungen, Pharm. Ind. 60 (2), 157-163, 1998
(65) Harnisch, S., Müller, R .H.,
Plasma protein adsorption patterns on emulsions for the parenteral
administration: Establishment of a protocol for two-dimensional polyacrylamide
electrophoresis. Electrophoresis, 19, 349-354,1998
(66) Lück, M., Pistel, K. F., Li, Y.-X., Blunk, T., Müller,
R. H., Kissel, T., Plasma protein adsorption on biodegradable
microspheres consisting of poly (DL-lactide-co-glycolide), poly(L-lactide)
or ABA triblock copolymers containing poly(oxyethylene): Influence of production
method and polymer composition, J. Control. Rel. 55,
107-120, 1998
(67) Leitzke, S., Bucke, W., Borner, K., Müller, R. H.,
Hahn, H., Ehlers, S., Rationale and efficacy of prolonged-interval
treatment using liposome-encapsulated Amikacin in experimental M. avium
infection, Antimicrob. Agents Chemother., 459-461,
1998
(68) Freitas, C., Müller, R. H.,
Spray Drying of Solid Lipid Nanoparticles (SLN™), Eur. J. Pharm. Biopharm.
46, 145-151, 1998
(69) Freitas, C., Müller, R. H., Effect
of light and temperature on zeta potential and physical stability in Solid
Lipid Nanoparticle (SLN™) Dispersions. Int. J. Pharm.
168, 221-229, 1998
(70) Thode, K., Lück, M., Schröder, W., Blunk, T., Müller,
R. H., Kresse, M., The influence of the sample preparation on plasma
protein adsorption patterns on polysaccharide-stabilized iron oxide particles
and N-terminal microsequencing of unknown proteins, J. Drug. Targ. 5 (6), 459-469, 1998
(71) Freitas, C., Müller, R. H.,
Correlation between long-term stability of solid lipid nanoparticles (SLN™) and
crystallinity of the lipid phase, Eur. J. Pharm. Biopharm. 47,
125-132, 1999
(72) Freitas, C., Müller, R. H.,
Stability Determination of Solid Lipid Nanoparticles (SLN™) in Aqueous
Dispersion after Addition of Electrolyte, Journal of Microencapsulation 16 (1),
59-71, 1999
(73) Müller, R. H., Dobrucki, R., Radomska, A.,
Solid lipid nanoparticles as a new formulation with retinol, Acta Poloniae
Pharmaceutica 56 (2), 117-120, 1999
(74) Müller, R. H., Böhm, B. H. L., Grau, M. J., Nanosuspensions - Formulierungen für schwerlösliche Arzneistoffe mit geringer Bioverfügbarkeit: I. Herstellung und Eigenschaften, Pharm. Ind. 61 (1), 74-78, 1999
(75) Müller, R. H., Böhm, B. H. L., Grau, M. J., Nanosuspensionen - Formulierungen für schwerlösliche Arzneistoffe mit geringer Bioverfügbarkeit: II. Stabilität, biopharmazeutische Aspekte, mögliche Arzneiformen und Zulassungsfragen, Pharm. Ind. 61 (2), 175-178, 1999
(76) Pinto, J. F., Müller, R. H., Pellets as carriers of solid lipid nanoparticles (SLN™) for oral administration of drugs, Die Pharmazie 54, 506-509, 1999
(77) Müller, R. H., Olbrich, C.,
Solid Lipid Nanoparticles (SLN): Phagocytic uptake, in vitro cytotoxity and in
vivo biodegradation, 1st Communication, Pharm. Ind.
61, 462-467, 1999
(78) Müller, R. H., Olbrich, C.,
Solid Lipid Nanoparticles (SLN): Phagocytic uptake, in vitro cytotoxity and in
vivo biodegradation, 2nd Communication, Pharm. Ind.
61, 564-569, 1999
(79) Olbrich, C., Müller, R. H.,
Enzymatic degradation of SLN - Effect of surfactant and surfactant mixtures,
Int. J. Pharm. 180, 31-39, 1999
(80) Peters, K., Müller, R. H., Craig, D. Q. M., An
Investigation into the Distribution of Lecithins [between Vesicles and Drug
Particles] in Nanosuspension Systems using Low Frequency Dielectric
Spectroscopy, Int. J. Pharm. 184, 53-61, 1999
(81) Dingler, A., Blum, R. P., Niehus, H., Gohla, S.,
Müller, R. H., Solid lipid nanoparticles (SLNTM/LipopearlsTM)
- A pharmaceutical and cosmetic carrier for the application of vitamin E in
dermal products, Journal of Microencapsulation 16 (6), 751-767, 1999
(82) Lück, M., Schröder, W., Paulke, B.-R., Blunk, T.,
Müller, R. H., Complement Activation by Model Drug Carries for
Intravenous Application: Determination by Two-Dimensional Electrophoresis,
Biomaterials 20, 2063-2068, 1999
(87) Müller, R. H., Olbrich, C.,
Solid Lipid Nanoparticles: Phagocytic uptake, in vitro cytotoxicity and in
vitro biodegradation, Drugs 42, 65-88, 1999
(89) Harnisch, S., Müller, R.H.,
Adsorption kinetics of plasma proteins on oil-in-water emulsions for parenteral
nutrition, Eur. J. Pharm. Biopharm. 49, 41-46, 2000
(107)Krause, W., Schlichter-Hackmann, N., Maier, F. K., Müller, R.
H., Dendrimers in Diagnostics, in: Topics in Current Chemistry. Vol.
210, 261-308, 2000
(116)Müller, R. H., Jacobs, C., Kayser, O., Nanosuspensions as
particulate drug formulations in therapy – Rationale for Development and what
we can expect for the future, in: Advanced Drug Delivery Reviews (ADDR) 47,
3-19, 2001
(1) Müller, R. H., Moderne Partikelmeßmethoden und ihre Anwendung in der Pharmazie, Teil 1: Mikroskopie und Weißlichtmessungen, Pharmazeutische Verfahrenstechnik heute 1, (12), 87-89, 1983
(2) Müller, R. H. , Moderne Partikelmeßmethoden und ihre Anwendung in der Pharmazie Teil 2: Meßverfahren unter Verwendung von Laserlicht, Pharmazeutische Verfahrenstechnik heute 1, (13), 91-94, 1983
(3) Müller, B. W. ,Müller, R. H., Bestimmung von mittleren Durchmessern und Größenverteilung an Teilchen im submikroskopischen Bereich mit der Photonenkorrelationsspektroskopie, Pharmazeutische Industrie 45, (11), 1150-1153, 1983
(4) Müller, R. H., Merz, J., Moderne Meßmethoden zur Bestimmung der Teilchenladung, Teil 1, Pharmazeutische Verfahrenstechnik heute 1, (20), 137-140, 1984
(5) Müller, R. H. und Merz, J., Moderne Meßmethoden zur Bestimmung der Teilchenladung, Teil 2, Pharmazeutische Verfahrenstechnik heute 1, (21), 141-144, 1985
(6) Müller, R. H., Heinemann, S., Drug Targeting. Kolloide Carrier zur intravenösen Applikation - Wunschtraum oder realistische Chance?, Deutsche Apotheker Zeitung 129 (41), 2188-2193, 1989
(7) Müller, B. W., Lucks, J. S., Stampa, B. und Müller, R. H., Effect of Anti-flocculants on Suspension Stability and Size Distribution - An investigation by laser light scattering techniques, Pharm. Ind. 52 (6), 789-793, 1990
(8) Müller, R. H., Heinemann, S., Smal, R., Stabilitätsbestimmung von Fettemulsionen zur parenteralen Ernährung, Deutsche Apotheker Zeitung 130 (6), 282-284, 1990
(9) Müller, R. H., Heinemann, S., Smal, R., Bestimmung der Organverteilung von Arzneiformen und Wirkstoffen durch Gamma-Szintigraphie, Deutsche Apotheker Zeitung 130 (8), 404-406, 1990
(10) Müller, R. H., Herbort, J., Lherm, C., Couvreur, P., Nanopartikel: Gewebsspezifische Arzneiform für Zytostatika, Deutsche Apotheker Zeitung 130 (27), 1509-1511, 1990
(11) Müller, R. H., Herbort, J., Smal, R., Heinemann, S., Latices: Polymerpartikel für Forschung und Arzneimittelherstellung, Deutsche Apotheker Zeitung 130 (21), 1210-1211, 1990
(12) Bräuer, A., Müller, R. H., Zellkulturen: Hepatozyten als In-vitro-Testsystem, Deutsche Apotheker Zeitung 130 (25), 1404-1405, 1990
(13) Müller, R. H., Herbort, J., Couvreur, P., Chiannilkulchai, N., Optimierung von Zytostatika-Formulierungen, Deutsche Apotheker Zeitung 131 (36), 1836-1837, 1991
(14) Müller, R. H., Waßmus, W., Smal, R., Koosha, F., Mikropartikel: Mikrodepots zur kontrollierten Arzneistoffabgabe, Deutsche Apotheker Zeitung 131 (40), 2049-2051, 1991
(15) Rudt, S., Smal, R., Müller, R. H., Chemilumineszenz-Assay: Untersuchung der Phagozytose von Arzneistoffträgern, Deutsche Apotheker Zeitung 132 (1/2), 10-11, 1992
(16) Rudt, S., Blunk, T., Müller, R. H., Quantification
of Cell Subpopulations, Fractions of Dead Cells and Debris in Cell Suspensions
by Laser Diffractometry, Pharm. Ind. 54 (11), 966-969, 1992
(17) Blunk, T. Mak, E., Müller, R. H., Characterization
of Colloidal Drug Carriers: Determination of surface hydrophobicity by
hydrophobic interaction chromatography, Pharm. Ind. 55 (6),
612-615, 1993
(18) Wallis, K. H., Müller, R. H., Determination
of the Surface Hydrophobicity of Colloidal Dispersions by Mini-Hydrophobic
Interaction Chromatography, Pharm. Ind. 55 (12), 1124-1128, 1993
(19) Wallis, K. H., Müller, R. H., Comparative
Measurements of Nanoparticle Degradation Velocity using an Accelerated
Hydrolysis Test, Pharm. Ind. 55 (2), 168-170, 1993
(20) Müller, R.H., Heinemann, S.,
Emulsions for Intravenous Administration. I. Emulsions for nutrition and drug
delivery, Pharm. Ind. 55 (9), 853-856, 1993
(21) Müller, R.H., Heinemann, S.,
Emulsions for Intravenous Application. II. Destabilisation and stabilisation
mechanisms in fat emulsions, Pharm. Ind. 55 (10), 948-953, 1993
(22) Schuhmann, R., Mehnert, W., Müller, R.H., Coulter Counter Based Coalescence Assay for the Determination of Emulsion Stability after Addition of Electrolyte, Pharm. Ind. 55 (7), 701-704, 1993
(23) Rudt, S., Müller, R.H., Messung der Chemilumineszenz zur Analytik und In-vitro-Testung von Arzneiformen, Pharm. Ind.56 (4), 393-396, 1994
(24) Diederichs, J. E, Müller, R. H., Liposome in Kosmetika und Arzneimitteln, Pharm. Ind. 56 (3), 267-275, 1994
(25) Huber, G.M.W., Becker, R., Müller, R.H., Zusammenhang zwischen Fließeigenschaften und Oberfläche pulverförmiger Rezepturen, Pharm. Ind. 56 (4), 389-392, 1994
(26) Müller, R.H., Paulke, B.-R., Kolloide als Arzneistoffträger in der Medizin,.Spektrum der Wissenschaft, 102-106, 1994
(27) Müller, R.H., Mehnert, W., Neue Arzneimittel mit Nanopartikeln - Innovationen in der Pharmazeutischen Technologie, Deutsche Apotheker Zeitung 135, 2597-2601, 1995
(28) Schuhmann, R., Müller, R.H., Analytik disperser Systeme mit Streulichtverfahren, Pharm. Ind., 57 (7), 579-584, 1995
(29) Schuhmann, R., Müller, R.H., Analytik disperser Systeme mit Streulichtverfahren, Österreichische Chemie 96, 198-203, 1995 (Nachdruck von Nr. 28)
(30) Schuhmann, R., Müller, R.H., Analytik disperser Systeme mit Streulichtverfahren, Chemie-Plus 1/2, 53-58, 1996 (Nachdruck von Nr. 28)
(31) Weyhers, H., Mehnert, W., Müller, R.H., Analysis of Particle Size Distribution of Micronized Lactose by Laser Diffractometry, Pharm. Ind. 58 (4), 354-357, 1996
(32) Schütt, D., Schuhmann, R., Müller, R.H., Genauer durch Mehrwinkelanalyse - Teilchengrößenmessung im Submikronbereich, Chemie-Technik 9, 18-20, 1996
(33) Weyhers, H., Mehnert, W., Müller, R.H.,
Analysis of Particle Size Distribution of Micronized Lactose by Laser
Diffractometry, Drugs made in Germany 40 (2), 1997 (Nachdruck von Nr. 31)
(34) Müller, R. H., Runge, S. A.,
Celowane podanie leku za pomoca koloidalnych nosników, Roczniki Naukowe, 1997
(35) Müller, R. H., Dingler, A., Feste Lipid-Nanopartikel (Lipopearls™) als neuartiger Carrier für kosmetische und dermatologische Wirkstoffe, Pharmazeutische Zeitung 49, Dermopharmazie, 11-15, 1998
(36) Müller, R. H., Dingler, A., The
next generation after the liposomes: solid lipid nanoparticles (SLN™,
Lipopearls™) as dermal carrier in cosmetics, Eurocosmetics 7/8, 19-26, 1998
(37) Müller, R. H., Harnisch, S.,
Characterization of fish vaccines and testing of administration properties,
Bull. Eur. Ass. Fish Pathol. 18
(6), 209-219, 1998
(38) Müller, R. H., Olbrich, C.,
Solid Lipid Nanoparticles (SLN): Phyagocytic uptake, in vitro cytotoxity and in
vivo biodegradation, Drugs made in Germany 42 (2), 49-53, 1999
(39) Kayser, O., Müller, R. H., Pharmazeutische Biotechnologie, Deutsche Apotheker Zeitung 139 (45), 4339-4343, 1999
(40) Müller, R. H., The European Association of Pharma Biotechnology Satellite
Meeting, Idrugs 3 No. 11, 2000
(41) Müller, R. H., Lipid-Nanopartikel (SLN, NLC) zur Verkapselung von kosmetischen Wirkstoffen, Kosmetikjahrbuch, 481-484, 2003
(1) Müller, R. H.,
Müller, B. W. Davis, S. S., Amplitude Weighted Phase
Structuration - a new Method for Simultaneous Charge and Size Determination of
Colloidal Drug Carriers, Proceed. 4th
International Conf. on Pharmaceutical Technology, 03. -
05.06. Paris, Vol. I, 205-214, 1986
(2) Müller, R. H.,
Davis, S. S., Illum, L. Mak, E., Surface Characterisation
of Colloidal Drug Carriers Coated with Polymers, Macromolecular Reprints,
161-162, 1986
(3) Davies, M. C.,
Wright, J., Koosha, F., Müller, R. H., Davis, S. S., Surface
Chemical Analysis and Site-Specific Delivery, Proceed. Int. Symp. Control. Rel. Bioact. Mater. 14,
111-112, 1987
(4) Müller, R. H.,
Heinemann, S. Niemann, W., Stability Determination of Parenteral Emulsions - a
Comparison of Conventional and Laser Light Scattering Techniques, J. Pharm. Pharmacol.
Suppl., 135, 1987
(5) Koosha, F.,
Müller, R. H., Washington, C., Production of Polyhydroxybutyrate
(PHB) Nanoparticles for Drug Targeting, J. Pharm. Pharmacol.
Suppl., 136, 1987
(6) Müller, R. H.,
Koosha, F., Davis, S. S. Illum, L., In Vitro and
in Vivo Release of In-111 from PHB and PLA Nanoparticles, Proceed. Int.
Symp. Control. Rel. Bioact. Mater.
15, 378-379, 1988
(7) Müller, R. H.,
Davis, S. S., Heinemann, S., Long-Term Stability of Regimens
for Total Parenteral Nutrition, J. Pharm. Pharmacol.
Suppl., 156, 1988
(8) Lucks, J. S.,
Müller, B. W., Stampa, B., Davis, S. S., Müller, R. H., Effect
of Anti-Flocculants on Stability and Elimination of Aggregates in Suspensions,
J. Pharm. Pharmacol. Suppl., 4, 1988
(9) Koosha, F.,
Müller, R. H., Davis, S. S., A Continous Flow System for In
Vitro Evaluation of Drug-Loaded Biodegradable Colloidal Carriers, J. Pharm. Pharmacol.
Suppl., 131, 1988
(10) Lherm, C., Müller, R. H., Herbort, J., Couvreur, P., Cytotoxicity
of Polyalkylcyanoacrylate Particles of Increasing Alkyl Chain Length, 5th Int.
Conf. on Pharm. Technol. (APGI) Vol. III, 81-88, 1989
(11) Diederichs, J. E., Weyhers, H., Müller, R. H., Parenteral
fat emulsions I. Effects of emulsion composition on the microviscosity of the
emulsifier film, Int. Symp. Control. Rel. Bioact. Mater. 18, 471-472, 1991
(12) Müller, R. H., Heinemann, S., Diederichs, J. E., Parenteral
fat emulsions II: Charge and rigidity of emulsifier film related to the
long-term stability, Int. Symp. Control. Rel. Bioact. Mater. 18, 469-470, 1991
(13) Müller, R. H., Rudt, S., Optimization
of a chemiluminescence based cell culture assay to study the affinity of
surface-modified drug carriers to macrophages, Int. Symp. Control. Rel. Bioact. Mater. 18,
219-220, 1991
(14) Carstensen, H., Müller, B. W., Müller, R. H., Characterization
of the properties of parenteral fat emulsions related to their uptake by the
RES, Int. Symp. Control. Rel. Bioact. Mater. 18, 473-474, 1991
(15) Lucks, J. S., Herbort, J., Chiannilkulchai, N.,
Müller, B. W., Couvreur, P., Müller, R. H., Water-soluble
metallocene derivatives as antitumor agents - reduced in vivo toxicity of
slowly decomposing complexes, Int. Symp. Control.
Rel. Bioact. Mater. 18, 419-420, 1991
(16) Bock, T., Müller, R. H., Müller, B. W., A
new assay for determining the hemolytic activity of drugs incorporated in
emulsions and liposomes, 6th Int. Conf. on Pharm. Technol. (APGI),
Vol. VI, 380-387, 1992
(17) Diederichs, J. E., Mehnert, W., Lucks, J. S., Müller,
R. H., Microviscosity measurements for the optimization of
liposomes and emulsion formulations, 6th Int. Conf. on
Pharm. Technol. (APGI), Vol. V, 138-147, 1992
(18) Lucks, J. S., Diederichs, J. E., Müller, B. W.,
Müller, R. H., Preparation and stability of sterically stabilized
soya oil emulsions, 6th Int. Conf. on Pharm. Technol. (APGI), Vol. V, 148-153, 1992
(19) Lucks, J. S., Baratt, G., Müller, B. W., Couvreur, P.,
Müller, R. H., Targeted controlled release formulations of titanocene
dichloride for the treatment of liver metastasis, 6th Int. Conf.
on Pharm. Technol. (APGI), Vol. II, 317-321, 1992
(20) Müller, R. H., Lucks, J. S., Diederichs, J. E.,
Heinemann, S., Egg lecithin stabilized emulsions for parenteral
nutrition - a three year stability study, 6th Int. Conf. on
Pharm. Technol. (APGI), Vol. IV, 351-360, 1992
(21) Diederichs, J. E., Mehnert, W., Müller, R. H., Differential
Scanning Calorimetry of parenteral fat emulsions, 6th Int. Conf.
on Pharm. Technol. (APGI), Vol. IV, 361-369, 1992
(22) Müller, R. H., Blunk, T., Carstensen, H., Müller, B.
W., Comparison of the physicochemical properties of
surface-modified colloidal drug carriers and fat emulsions for intravenous
injection, 6th Int. Conf. on Pharm. Technol. (APGI), Vol. V, 174-184, 1992
(23) Blunk, T., Hochstrasser, D. F., Müller, B.W., Müller,
R.H., Differential adsorption: Effect of plasma protein
adsorption patterns on organ distribution of colloidal drug carriers, Int. Symp.
Control. Rel. Bioact. Mater.
20, 256-257, 1993
(24) Blunk, T., Hochstrasser, D. F., Müller, B.W., Müller,
R.H., 2-D PAGE analysis of plasma protein adsorption on
colloidal drug carriers, Int. Symp. Control. Rel. Bioact. Mater. 20, 284-285, 1993
(25) Diederichs, J.E., Müller, R.H.,
Microviscosity of bovine surfactant liposomes for the treatment of IRDS, Int. Symp.
Control. Rel. Bioact. Mater.
20, 488-489, 1993
(26) Diederichs, J.E., Müller, R.H.,
Production and characterization of bovine surfactant liposomes for the
treatment of IRDS, Int. Symp. Control. Rel. Bioact. Mater. 20, 482-483, 1993
(27) Müller, R.H., Schwarz, C., Mehnert, W., Lucks, J.S.,
Production of solid lipid nanoparticles (SLN) for controlled drug delivery,
Int. Symp. Control. Rel. Bioact. Mater. 20, 480-481, 1993
(28) Maaßen, S., Schwarz, C., Mehnert, W., Lucks, J.S.,
Yunis-Specht, F., Müller, B.W., Müller, R.H., Comparison
of cytotoxicity between polyester nanoparticles and solid lipid nanoparticles
(SLN), Int. Symp. Control. Rel. Bioact. Mater. 20, 490-491, 1993
(29) Müller, R.H., Schwarz, C., zur Mühlen, A., Mehnert, W.,
Incorporation of Lipophilic Drugs and Drug Release profiles of Solid Lipid
Nanoparticles (SLN), Int. Symp. Control. Rel. Bioact. Mater. 21, 146-147, 1994
(30) Blunk, T., Bock, T.K., Hochstrasser, D.F., Sanchez,
J.C., Müller, B.W., Müller, R.H., Plasma Protein Adsorption
Patterns on Fat Emulsions compared to Modified Latex Particles, Int. Symp.
Control. Rel. Bioact. Mater.
21, 503-504, 1994
(31) Diederichs, J.E., Vauthier, C., Alphandary, H.,
Couvreur, P., Müller, R.H., Formation Process and Determination of
Microviscosity of Alginate Nanoparticles, Int. Symp. Control. Rel. Bioact. Mater. 21, 511-512,
1994
(32) Blunk, T., Lück, M., Hochstrasser, Sanchez, J.C.,
Müller, B.W., Müller, R.H., Kinetics of Protein Adsorption on
Colloidal Drug Carriers for Drug Targeting. Evaluation by HR-Two-Dimensional
Polyacrylamide Gel Electrophoresis, Proc. of 2D Electrophoresis: from protein
maps to genomes, Siena, Italien, 100-101, 1994
(33) Herbort, J., Diederichs, J.E., Müller, R.H.,
Particle size analysis of liposomes in hydrogels by photon correlation
spectroscopy (PCS), 1st World Meeting on Pharmaceutics,
Biopharmaceutics, Pharmaceutical Technology, APGI/APV, Budapest, 555-556, 1995
(34) Bucke, W.E., Ehlers, S., Leitzke, S., Diederichs,
J.E., Hahn, H., Müller, R.H., Optimized liposomal amikacin
for treatment of disseminated mycobacterial infections, 1st World
Meeting on Pharmaceutics, Biopharmaceutics, Pharmaceutical Technology,
APGI/APV, Budapest, 545-546, 1995
(35) Müller, R.H., Mehnert, W., Potential of
Solid Lipid Nanoparticles (SLN) for Controlled Drug Delivery, 1st
World Meeting on Pharmaceutics, Biopharmaceutics, Pharmaceutical Technology,
APGI/APV, Budapest, 463-464, 1995
(36) Weyhers, H., Ehlers, S.,Mehnert, W.,Hahn, H., Müller,
R.H., "Solid Lipid Nanoparticles" -
determination of in vivo toxicity, 1st World Meeting on
Pharmaceutics, Biopharmaceutics, Pharmaceutical Technology, APGI/APV, Budapest,
489-490, 1995
(37) Rühl, D., Paulke, B.-R., Maurer, H.R., Müller, R.H.,
Phagocytic uptake of polymeric particles in vitro - effect of surface
hydrophobicity and fluorescent labeling, 1st World Meeting on
Pharmaceutics, Biopharmaceutics, Pharmaceutical Technology, APGI/APV, Budapest,
525-526, 1995
(38) Eckstein, B., Diederichs, J.E., Burger, J.J., Sloot,
E.A., Müller, R.H., Analytical approach to determine the effect of azo
dyes on the physical stability of stabilized o/w emulsions, 1st
World Meeting on Pharmaceutics, Biopharmaceutics, Pharmaceutical Technology,
APGI/APV, Budapest, 660-661, 1995
(39) Müller, R.H., Peters, K., Becker, R., Kruss, B.,
Nanosuspensions - a novel formulation for the i.v. administration of poorly
soluble drugs, 1st World Meeting on Pharmaceutics, Biopharmaceutics,
Pharmaceutical Technology, APGI/APV, Budapest, 491-492, 1995
(40) Freitas, C., Lucks, J.S., Müller, R.H.,
Effect of storage conditions on long-term stability of "Solid Lipid
Nanoparticles" (SLN) in aqueous dispersion, 1st World Meeting
on Pharmaceutics, Biopharmaceutics, Pharmaceutical Technology, APGI/APV,
Budapest, 493-494, 1995
(41) Thode, K., Kresse, M., Pfefferer, D., Semmler, W.,
Müller, R.H., Mini-HIC for the determination of the surface
hydrophobicity of magnetite dispersions, 1st World Meeting on
Pharmaceutics, Biopharmaceutics, Pharmaceutical Technology, APGI/APV, Budapest,
509-510, 1995
(42) Kresse, M., Pfefferer, D., Thode, K., Müller, R.H.,
Semmler, W., Estimation of hydrodynamic sizes of dextran coated
iron oxide nanoparticles by size exclusion chromatography (SEC), 1st
World Meeting on Pharmaceutics, Biopharmaceutics, Pharmaceutical Technology,
APGI/APV, Budapest, 507-508, 1995
(43) Blunk, T., Lück, M., Müller, B.W., Müller, R.H.,
Influence of polyethylene oxide chains on the protein adsorption on
nanoparticles for drug targeting, 1st World Meeting on
Pharmaceutics, Biopharmaceutics, Pharmaceutical Technology, APGI/APV, Budapest,
531-532, 1995
(44) Müller, R.H., Peters, K., Becker, R., Kruss, B.,
Nanosuspensions for the i.v. Administration of Poorly Soluble Drugs - Stability
During Sterilization and Long-Term Storage, Int. Symp. Control. Rel. Bioact. Mater. 22,
574-575, 1995
(45) Diederichs, J.E., Eckstein, B., Müller, R.H.,
Influence of Divalent Cations on the Coalescence Kinetics of Parenteral Fat
Emulsions - Fusion Properties of Calcium Ions, Int. Symp. Control. Rel. Bioact. Mater. 22,
378-379, 1995
(46) Blunk, T., Lück, M., Diederichs, J.E., Müller, B.W.,
Müller, R.H., Plasma Protein Adsorption on Polystyrene Particles of
Different Size Modified with Poloxamer 407, Int. Symp. Control. Rel. Bioact. Mater. 22,
47-48, 1995
(47) Schwarz, C., Freitas, C., Mehnert, W., Müller, R.H.,
Sterilization and Physical Stability of Drug-Free and Etomidate-Loaded Solid
Lipid Nanoparticles, Int. Symp. Control. Rel. Bioact. Mater. 22, 766-767, 1995
(48) Peters, K., Müller, R.H., Nanosuspensions
for the oral application of poorly soluble drugs, Proceeding European Symposium
on Formulation of Poorly-available Drugs for Oral Administration, APGI, Paris,
330-333, 1996
(49) Müller, R.H., Peters, K., Craig, D.,
Electron microscopic studies of nanosuspensions - particle shapes as a funktion
of drug and surfactant, Int. Symp. Control. Rel. Bioact. Mater. 23, 925-926, 1996
(50) Müller, R.H., zur Mühlen, A., Freitas, C.,
Solid Lipid Nanoparticles (SLN) for intravenous drug delivery, Int. Symp. Control. Rel. Bioact. Mater. 23,
184-185, 1996
(51) Diederichs, W.E., Leitzke, J.E., Bucke, S., Borner, K., Ehlers, S., Hahn, H., Müller, R.H., Superiority of Liposomal Amikacin - A comparison with free drug admixed to colloidal carriers, Int. Symp. Control. Rel. Bioact. Mater. 23, 659-660, 1996
(52) Schuhmann R., Müller, R.H., Optimierung der Probenaufbereitung für Coulter-Counter-Messungen, Proceedings Seminar mit Praktikum: Probenpräparation und Partikelmeßtechnik, George-Simon-Ohm-Fachhochschule Nürnberg, Fachbereich Verfahrenstechnik und Coulter Electronics GmbH, 25./26.6.1996
(53) Pistel, K.F., Lück, M., Müller, R.H. and Kissel, T., Plasma
Protein Adsorption on Biodegradable Microspheres Consisting of Polyesters or
ABA Triblock Copolymers, Int. Symp. Control. Rel. Bioact. Mater. 24, 765-766, 1997
(54) Almeida, A.J., Runge, S., Müller, R.H., Investigations
on solid lipid nanoparticles (SLN) as colloidal carriers for protein antigens,
Int. Symp. Control. Rel. Bioact. Mater. 24, 837-838, 1997
(55) Diederichs, J.E., Herbort, J., Müller, R.H., Long-term
stability of liposomes in hydrogels, Int. Symp. Control. Rel. Bioact. Mater. 24,
845-846 (1997)
(56) Harnisch, S., Müller, R.H., Analysis
of adsorbed plasma proteins on commercial emulsions for parenteral nutrition,
Int. Symp. Control. Rel. Bioact. Mater. 24, 847-848, 1997
(57) Lück, M, Schröder, W., Paulke, B.-R., Müller, R.H., Identification
of plasma proteins adsorbed on polystyrene model particles, Int. Symp.
Control. Rel. Bioact. Mater.
24, 849-850, 1997
(58) Müller, R.H., Peters, K., Nanosuspensions
- based drug formulations - a solution for poorly soluble & bioavailable
drugs, Int. Symp. Control. Rel. Bioact. Mater. 24, 863-864, 1997
(59) Olbrich, C., Mehnert, W., Müller, R.H., Effect
of surfactant and lipid composition on the in vitro degradation time of solid
lipid nanoparticles (SLN), Int. Symp. Control. Rel.
Bioact. Mater. 24, 921-922, 1997
(60) Müller, R.H., Mehnert, W., Dingler, A., Runge, S.A.,
zur Mühlen, A., Freitas, A., Solid lipid nanoparticles (SLN™,
Lipopearls™) - present state of development, Int. Symp. Control. Rel. Bioact. Mater. 24,
923-924, 1997
(61) Dingler, A., Hildebrand, G.E., Kielholz, J., Pfeiffer,
S., Debus, N., Müller, R.H., Gohla, S., Electron and
fluorescence micrographical characterisation of lipopearls™ (SLN™), Int. Symp.
Control. Rel. Bioact. Mater.
24, 925-926, 1997
(62) Böhm, B.H.L., Behnke, D., Müller, R.H., Production
of paclitaxel nanosuspensions by high-pressure homogenisation, Int. Symp.
Control. Rel. Bioact. Mater.
24, 927-928, 1997
(63) Harnisch, S., Schuhmann, R., Müller, R.H., Calcium-induced
coalescence-effect of emulsion dilution on coalescence kinetices, Int. Symp.
Control. Rel. Bioact. Mater.
24, 929-930, 1997
(64) Müller, R.H., Diederichs, J.E., Bucke, W.E., Controlled
enhancement of drug incorporation into liposomes by ascorbic acid palmitate
(AP), retinol palmitate (RP) and tocopherol acetate (TA), Int. Symp.
Control. Rel. Bioact. Mater.
24, 931-932, 1997
(65) Hildebrand, G.E., Herbort, J., Diederichs, J.E.,
Müller, R.H., Fluorescence polarization studies in micelles to
monitor changes in colloidal structures, Int. Symp. Control. Rel. Bioact. Mater. 24,
933-934, 1997
(66) Dingler, A., Lukowski, G., Pflegel, P., Müller, R.H.,
Gohla, S., Production and characterisation of lipopearls™ for
cosmetics, Int. Symp. Control. Rel. Bioact. Mater. 24, 935-936, 1997
(67) Lück, M., Pistel, K.F., Kissel, T., Müller, R.H.,
Influence of the production method on protein adsorption of biodegradable
microspheres, Int. Symp. Control. Rel. Bioact. Mater. 24, 937-938, 1997
(68) Müller, R.H., Peters, K., Craig, D.,
Investigations of nanosuspensions with low-frequency dielectric analysis, Int. Symp.
Control. Rel. Bioact. Mater.
24, 991-992, 1997
(69) Kresse, M., Wagner, S., Philipp, K., Thode, K.,
Müller, R.H., Semmler, W, Synthesis and Properties of Dexrtran-coated Iron
Oxides for Lymph Node Targeting, Int. Symp. Control.
Rel. Bioact. Mater. 24, 93-94, 1997
(70) Harnisch, S.. Schuhmann, R.,
Thode, K., Müller, R.H., Improvements on particle sizing using a laser
diffractometer equipped with the PIDS technology, 2nd World Congress
on Emulsion, Bordeaux, 2-1-197, 1997
(71) Dingler, A., Lukowski, G., Pflegel, P., Gohla, S.,
Müller, R.H., Production of solid lipid nanoparticles (SLNTM)
from cosmetic lipids and surfactants, 2nd World Congress on
Emulsion, Bordeaux, 4-2-297, 1997
(72) Harnisch, S., Blunk, T., Müller, R.H.,
Analysis of plasma protein adsorption on commercial emulsions for intravenous
parenteral nutrition, 2nd World Congress on Emulsion, Bordeaux,
4-2-199, 1997
(73) Dingler, A., Lukowski, G., Gohla, S., Müller, R.H., Production
and characterisation of solid lipid nanoparticles as colloidal carrier system
for cosmetic products, 2nd World Congress on Emulsion, Bordeaux,
4-2-296, 1997
(74) Dingler, A., Hildebrand, G.E., Kielholz, J., Gohla,
S., Müller, R.H., Fluorescence and electron microscopic characterisation
of solid lipid nanoarticles in aqueous dispersions and ointments, 2nd
World Congress on Emulsion, Bodeaux, 4-2-297, 1997
(75) Müller, R.H., Gohla, S., Hildebrand, G., Runge, S.A.,
Dingler, A, Dispersion of solid lipid nanoparticles (SLN):
Production and possible applications in food, cosmetic and pharmaceutical
products, 2nd World Congress on Emulsion, Bordeaux, 1-2-195, 1997
(76) Harnisch, S., Schuhmann, R., Müller, R.H., A
Coulter Counter based assay for high resolution analysis of the coalescence kinetics
of oil-in-water emulsions, 2nd World Congress on Emulsion, Bordeaux,
2-3-198, 1997
(77) Böhm, B.H.L., Grau, M.J., Hildebrand, G.E., Thünemann,
A.F., Müller, R.H., Preparation and Physical Properties of
Nanosuspensions (Dissocubes™) of Poorly Soluble Drugs, Int. Symp.
Control. Rel. Bioact. Mater.
25, 956-957, 1998
(78) Müller, R.H., Dingler, A., Hildebrand, G.E., Gohla, S.,
Development of Cosmetic Products (Lipopearls™) based on Solid Lipid
Nanoparticles, Int. Symp. Control. Rel. Bioact. Mater. 25, 238-239, 1998
(79) Dingler, A., Hildebrand, G., Niehus, H., Müller, R.H.,
Cosmetic Anti-Aging Formulation Based on Vitamin E-Loaded Solid Lipid
Nanoparticles, Int. Symp. Control. Rel. Bioact. Mater. 25, 433-434, 1998
(80) Hildebrand, G.E., Dingler, A., Runge, S.A., Müller,
R.H., Medium Scale Production of Solid Lipid Nanoparticles
(SLN), Int. Symp. Control. Rel. Bioact. Mater. 25, 968-969, 1998
(81) Haeckel, S., Sachse, A., Albayrak, C., Müller, R.H.,
Preparation and characterization of insulin-loaded PLGA-microcapsules produced
by the induced phase separation method, 2nd World Meeting on
Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology APGI/APV, Paris,
507-508, 1998
(82) Dingler, A., Müller, R.H., Gohla, S.,
Incorporation of Hydrophilic Active Ingredients in Solid Lipid Nanoparticles
for the Topical Application, 2nd World Meeting on Pharmaceutics,
Biopharmaceutics and Pharmaceutical Technology APGI/APV, Paris, 625-626, 1998
(83) Harnisch, S., Buszello, K., Müller, B.W., Müller, R.H.,
Influence of the Composition of Oil in Water Emulsions on the Pattern of
Adsorbed Plasma Proteins, 2nd World Meeting on Pharmaceutics,
Biopharmaceutics and Pharmaceutical Technology APGI/APV, Paris, 773-774, 1998
(84) Olbrich, C., Mehnert, W., Müller, R.H., In
vitro Degradation Properties of Solid Lipid Nanoparticles SLN™, 2nd
World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology
APGI/APV, Paris, 577-578, 1998
(85) Olbrich, C., Mehnert, W., Müller, R.H., Development
of an in vitro Degradation Assay for Solid Lipid Nanoparticles, 2nd
World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology
APGI/APV, Paris, 627-628, 1998
(86) Schütt, D.H., Kaiser, Stamm, I., Kubis, A., E.,
Müller, R.H., New Generation of Cosmetic Products Based on Solid
Lipid Nanoparticles (Lipopearls™), 2nd World Meeting on
Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology APGI/APV, Paris,
585-586, 1998
(87) Jenning, V., Gohla S., Müller R.H.,
Solid Lipid Nanoparticles (SLN): Effect of homogenization parameters on drug
stability, 2nd World Meeting on Pharmaceutics, Biopharmaceutics and
Pharmaceutical Technology APGI/APV, Paris, 619-620, 1998
(88) Böhm, B.H.L, Behnke, D., Müller, R.H., Paclitaxel
Nanosuspensions: Production, Lyophilisation and Stability, 2nd World
Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology
APGI/APV, Paris, 621-622, 1998
(89) Grau, M.J., Müller, R.H., Increase of
Dissolution Velocity and Solubility of Poorly Soluble Drugs by Formulation as
Nanosuspension, 2nd World Meeting on Pharmaceutics, Biopharmaceutics
and Pharmaceutical Technology APGI/APV, Paris, 623-624, 1998
(90) Geßner, A., Lück, M., Paulke, B.R., Müller, R.H.,
Analysis of Plasma Protein Adsorption on Model Particles by Two-Dimensional
Electrophoresis - Methodical Aspects, 2nd World Meeting on
Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology APGI/APV, Paris,
615-616, 1998
(91) Seehof, K., Harnisch, S., Kresse, M, Semmler, W.,
Müller, R.H., Protein Adsorption Patterns on to Iron Oxide MRI
Contrast Media, Results for Citrated and Heparinized Human Plasma, 2nd
World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology
APGI/APV, Paris, 617-618, 1998
(92) Peters, K., Leitzke, S., Ehlers, S., Borner, K., Hahn,
H., Müller, R.H., Preparation of a clofazimine nanosuspension for i.v.
administration, 2nd World Meeting on Pharmaceutics, Biopharmaceutics
and Pharmaceutical Technology APGI/APV, Paris, 609-610, 1998
(93) Lück, M., Schröder, W., Paulke, B.R., Müller, R.H., Binding
of Complement Protein C3 to Model Drug Carriers for i.v. Application -
Determination by 2-D Electrophoresis, 2nd World Meeting on
Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology APGI/APV, Paris,
607-608, 1998
(94) Anger, S., Mehnert, W., Caldwell, K., Müller, R.H.,
High resolution determination of adsorption layer mass on particles by
sedimentation field-flow fractionation, 2nd World Meeting on
Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology APGI/APV, Paris,
643-644, 1998
(95) Kresse, M., Thode, K., Wagner, S., Müller, R.H.,
Semmler, W., Ex vivo investigations into the opsonization of
iron-oxide-based contrast media for MRI, 2nd World Meeting on Pharmaceutics,
Biopharmaceutics and Pharmaceutical Technology APGI/APV, Paris, 611-612, 1998
(96) Kresse, M., Thode, K., Müller, R.H.,
Multi-angle and two-time window analysis: detection of aggregates in iron-oxide
dispersions, 2nd World Meeting on Pharmaceutics, Biopharmaceutics
and Pharmaceutical Technology APGI/APV, Paris, 37-38, 1998
(97) Krause, W., Schlichter, N., Maier, F. K., Sachse, A.,
Müller, R. H., Contrast Agents Based on Dendrimers and Vesicles,
DECHEMA Symposion „Polymers for Medicinal Technologies, Tutzing, 8-11 March
1999
(110) Baudisch, U.
Briel, A., Rößling, G., Müller, R. H., Investigation
of the glass transition temperature of polybutylcyanoacrylate polymers, 3rd
World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology
APGI/APV, Berlin, 423-424, 2000
(1) Müller, R.H., Müller, B.W., Teilchengrößenbestimmungen an Mikroemulsionen mit Hilfe der Laser-Korrelationsspektroskopie, Acta Pharm. Technol. 28, 91, 1982
(2) Müller, B.W., Müller, R.H.,
Schulz-DuBois, E.O.,
Zetapotentialmessungen an hochdispersen Systemen mit Hilfe der Laser Doppler
Anemometrie, Acta Pharm. Technol. 28, 90, 1982
(3) Müller, R.H., Mak, E., Analysis of Particle Charge and Surface Hydrophobicity of Colloidal Drug Carriers. NATO Advanced Studies Institute Meeting "Targeting of Drugs with Synthetic Systems", 24.06.-25.07. Cape Sounion Beach (Greece), 1985
(4) Davis, S.S., Illum, L., Mak, E.,
Müller, R.H., AWPS
zur Ladungsbestimmung kolloider Arzneistoffträger, Arch. Pharm.318,
1985
(5) Müller, R.H.,
Davis, S.S., Illum, L., Mak, E., Colloidal Carriers for Drug
Targeting - Charge Reduction by Coating with Polymers, Acta Pharm. Technol.
32, 1986
(6) Mak, E., Davis, S.S., Illum, L., Müller, R.H., Determination of the Surface Hydrophobicity of Colloidal Drug Carriers using a Rose Bengal Binding Method, Acta Pharm. Technol. 32, 1986
(7) Müller, R.H., Davis, S.S., Nehne, J., Vergleich von Analysenmethoden zur Stabilitätsuntersuchung von parenteralen Fettemulsionen, Gemeinsame Tagung der Österreichischen und Deutschen Pharmazeutischen Gesellschaft, 10.-12.06. Innsbruck, Scientia Pharmaceutica 3, 224, 1986
(8) Müller, R.H., West, P.E., Koosha, F.,
Davis, S.S., Coulter
Counter und Laserdiffraktometer - Vergleich der beiden Meßmethoden, Gemeinsame
Tagung der Österreichischen und Deutschen Pharmazeutischen Gesellschaft,
10.-12.06. Innsbruck, Scientia Pharmaceutica 3, 225, 1986
(9) Mak, E.,
Davis, S.S., Illum, L., Müller, R.H.,
Determination of Surface Properties of 'Standard' Latex Particles, British
Pharmaceutical Conference, 22.-24.09. Jersey, 100, 1986
(10) Müller, R.H., Davies, M.C., Koosha, F.,
Surface Analysis of PHB Drug Carriers by SSIMS, 2nd Int. Conference
on Biointeractions, 06.-08.07. Cambridge, 1987
(11) Müller, R.H., Mak, E., Davis, S.S., Cairns, S.,
Aqueous Two Phase Partitioning for the Surface
Characterisation of Colloidal Drug Carriers. 5th Int.
Conference on Phase Partitioning, 24.-28.08. Oxford, 1987
(12) Müller, R.H., Drug
Targeting mit kolloidalen Carriern - Limitationen und Möglichkeiten, Arch.
Pharm. 320, 912, 1987
(13) Müller, R.H., Wowk, I., Controlled
Surface Modification of Model Drug Carriers, Arch. Pharm. 320,
982, 1987
(14) Koosha, F., Müller, R.H., Production
of Polyhydroxybutyrate (PHB) Micro- and Nanoparticles, Arch. Pharm.
320, 913, 1987
(15) Müller, R.H., Koosha, F., Davies, M.C.,
Determination of Toxic Residues in Drug Carriers by SSIMS, Arch. Pharm.
320, 980, 1987
(16) Galazka, V., Khan, A.M., Davies, M.C., Müller, R.H., Effect of Gamma Iridation and Plasma Etching on the Surface of Polymers, Arch. Pharm. 320, 983, 1987
(17) Müller, R.H., Heinemann, S., Stabilitätsuntersuchungen an
TPN-Regimen, Arch. Pharm. 320, 981, 1987
(18) Koosha, F., Müller, R.H., Radioactive
Labelling of Biodegradable PHB and PLA Drug Carriers, Acta Pharm. Technol.
34, 24S, 1988
(19) Koosha, F., Müller, R.H., Production
of Polymeric Drug Carriers for Drug Targeting, Acta Pharm. Technol.
34, 24S, (1988)
(20) Müller, R.H., Nehne, J., Davis, S.S., Heinemann, S.,
Characterization of Fat Emulsions for Parenteral Nutrition, Acta Pharm. Technol.
34, 23S, 1988
(21) Müller, R.H., Davis, S.S., Niemann, W.,
Stability Assessment of Feeding Mixtures for Parenteral Nutrition (TPN), Acta
Pharm. Technol. 34, 17S, 1988
(22) Davies, M.C., Koosha, F., Müller, R.H.,
The Surface Analysis of Micro- and Nanoparticles by SSIMS, Acta Pharm. Technol.
34, 21S, 1988
(23) Mak, E., Müller, R.H., Davis, S.S., Illum, L.,
Hydrophobic Interaction Chromatography (HIC) and Laser doppler Anemometry (LDA)
for the Characterization of Coated Drug Carriers, Acta Pharm. Technol.
34, 23S, 1988
(24) Mak, E., Müller, R.H., Davis, S.S., Illum, L.,
Characterization of Colloidal Carriers for Drug Targeting, Acta Pharm. Technol.
34, 20S, 1988
(25) Müller, B.W., Lucks,J.S., Stampa, B., Müller, R.H.,
Effect of Anti-Flocculating Agents on the Zeta Potential of Dispersions, Acta
Pharm. Technol. 34, 23S, 1988
(26) Müller, B.W., Stampa, B., Lucks, J.S., Müller, R.H.,
AWPS - Zeta Potential Measurements in Low Electrical Fields under the
Elimination of the Stationary Layer, Acta Pharm. Technol. 34,
23S, 1988
(27) Bräuer, A., Wollesen, C., Jones, P.D.E., Müller, R.H.,
Hepatocyte Cultures for the Testing of Colloidal Drug Delivery Systems, Arch. Pharm
321, 684, 1988
(28) Müller, R.H., Lucks, J.S., Davis, S.S., Wallis, K.,
Long Term Stability of Parenteral Fat Emulsions, Arch. Pharm 321,
676, 1988
(29) Müller, R.H., Blunk, T., Koosha, F., Davis, S.S.,
Determination of Surface Hydrophobicity of Colloidal Polymeric and Emulsion
Drug Carriers, Arch. Pharm 321, 677, 1988
(30) Müller, R.H., Blunk, T., Koosha, F.,
Determination of the Thickness of Adsorbed Polymer Layers on Colloidal Drug
Carriers by Charge Measurements, Arch. Pharm 321,
678, 1988
(31) Roberts, M.J.J., Müller, R.H., Gupta, A., Williams,
P., Davies, M.C., Davis, S.S., The Production of Monodisperse
Polystyrene Latexes of a Range of Nominal Particle Sizes, Arch. Pharm
321, 679, 1988
(32) Koosha, F., Müller, R.H., Nanoparticle
Production by Microfluidization, Arch. Pharm 321,
680, 1988
(33) Lucks, J.S., Müller, B.W., Müller, R.H., Effect of Electrolytes on the Stability of Parenteral Fat Emulsions, Arch. Pharm 321, 683, 1988
(34) Müller, B.W., Lucks, J.S., Müller,
R.H., Effektivität
des Peptisatorzusatzes nach DIN 51033 zur Stabilitätserhöhung von Suspensionen,
Arch. Pharm 321, 616, 1988
(35) Lherm, C., Müller, R.H., Blunk, T., Perie, M.,
Depraetere, P., Couvreur, P., Physico-Chemical
Characterisation of Cyanoacrylate Particles, Arch. Pharm 321,
682, 1988
(36) Müller, R.H., Lherm, C., Jaffray, P., Couvreur, P.,
Toxicity of Cyanoacrylate Particles in L929 Fibroblast Cell Cultures - Relation
between Toxicity and In Vitro Characterization Parameters, Arch. Pharm
321, 681, 1988
(37) Müller, R.H., Lucks, J.S., Relevance of
Stress Tests for the Estimation of the Long-term Stability of Parenteral Fat
Emulsions, Arch. Pharm 321, 685, 1988
(38) Müller, R.H., Koosha, F., In Vitro
Characterization of i.v. Drug Carriers - a New Theory of the Relevant Factors
Determining Their In Vivo Behaviour, Arch. Pharm 321,
622, 1988
(39) Müller, R.H., Blunk, T., Properties
of Poloxamer and Poloxamine Coating Layers on Different Sized Polystyrene Model
Drug Carriers, Arch. Pharm 322, 699, 1989
(40) Müller, R.H., Differential
Opsonization - a New Approach for the Targeting of Colloidal Drug Carriers,
Arch. Pharm 322, 700, 1989
(41) Lucks, J.S., Müller, B.W., Müller, R.H.,
Stability of Mixed Emulsion Systems Containing
Egg Lecithin and Ethoxylated Surfactants, Arch. Pharm 322,
704, 1989
(42) Bräuer, A., Aschmann, C., Müller, R.H.,
Ethoxylated Surfactants for the Coating of Colloidal Drug Carriers -
Interaction with Hepatocytes in Culture, Arch. Pharm. 322,
754, 1989
(43) Blunk, T., Müller, R.H., Uptake of
Charged Serum Components as a Selection Criterion for i.v. Drug Carriers
Avoiding Liver / Spleen Uptake, Arch. Pharm. 322, 755, 1989
(44) Lherm, C., Herbort, J., Müller, R.H., Couvreur, P.,
Fluorescent Labelling of Polyalkylcyanoacrylate Particles - Optimization of
Labelling Conditions, Arch. Pharm. 322, 760, 1989
(45) Müller, R.H., Landry, F.B.,
Characterization of Aluminum Hydroxide Suspensions by Laser Light Scattering
Techniques, Arch. Pharm. 322, 762, 1989
(46) Lherm, C., Herbort, J., Müller, R.H., Couvreur, P.,
In Vitro Degradation of Polyalkylcyanoacrylate Particles - Influence of Alkyl
Chain Length and Incubation Medium, Arch. Pharm. 322,
763, 1989
(47) Lucks, J.S., Müller, B.W., Müller, R.H.,
Microfluidizer and Micron Lab 40 - Influence of
Homogenization Parameters on Particle Size, Arch. Pharm. 322,
764, 1989
(48) Müller, R.H., Wallis, K.H., Stability of
Poloxamer and Poloxamine Coating Films on Colloidal Drug Carriers, Arch. Pharm.
322, 768, 1989
(49) Wallis, K.H., Müller, R.H., In
Vitro Degradation Model for PLA, PLA/GA and PHB Nanoparticles, Arch. Pharm. 322,
769, 1989
(50) Lherm, C., Müller, R.H., Couvreur, P.,
Cytotoxicity of Polyalkyl-Cyanoacrylate Particles in L929 Fibroblast Cultures -
Mechanism of the Toxic Effect, Arch. Pharm. 322, 682, 1989
(51) Müller, R.H., Differential
adsorption for the targeting of drug carriers, Acta Pharm. Technol.
36, 34S, 1990
(52) Wallis, K., Müller, R.H.,
Surface-modified colloidal drug carriers - determination of the dysopsonic
effect by PCS, Acta Pharm. Technol. 36, 34S, 1990
(53) Blunk, T., Müller, R.H., Measurement
of the surface hydrophobicity of parenteral fat emulsions as an important
parameter for RES impairment, Acta Pharm. Technol. 36,
34S, 1990
(54) Lherm, C., Herbort, J., Müller, R.H., Couvreur, P.,
Degradation studies on surface-modified alkyl-cyanoacrylate nanoparticles, Acta
Pharm. Technol. 36, 33S, 1990
(55) Bräuer, A., Lherm, C., Couvreur, P., Müller, R.H., Cytotoxicity of alkyl-cyanoacrylate nanoparticles in fibroblast and hepatocyte cultures, Acta Pharm. Technol. 36, 33S, 1990
(56) Lucks, J.S., Müller, B.W., Müller, R.H., Wechselwirkungen parenteraler Fettemulsionen mit Peptisatoren, Acta Pharm. Technol. 36, 33S, 1990
(57) Stampa, B., Lucks, J.S., Müller, B.W.,
Müller, R.H.,
Polarisationsdekodierte AWPS - Simultane Messung von Zetapotential und
Teilchengrößenverteilung, Acta Pharm. Technol. 36, 33S, 1990
(58) Müller, R.H., Herbort, J., Production
of polystyrene particles and particles with incorporated gold core for use as
model drug carriers, Arch. Pharm. 323, 775, 1990
(59) Wallis, K.H., Müller, R.H., Mini-HIC for
the rapid determination of the surface hydrophobicity of colloidal particles,
Arch. Pharm. 323, 766, 1990
(60) Carstensen, H., Müller, B.W., Müller, R.H.,
Microcalorimetric studies of the adsorption of ethoxylated surfactants on
polystyrene particles, Arch. Pharm. 323, 776, 1990
(61) Bräuer, A., Müller, R.H., Toxicity of
cyanoacrylate nanoparticles, degradation products and Doxorubicin-containing
particles, Arch. Pharm. 323, 763, 1990
(62) Rudt, S., Bräuer, A., Veit, A., Maurer, R., Müller,
R.H., Chemiluminescence for the testing of particulate
drug carriers in cell suspension, Arch. Pharm. 323,
774, 1990
(63) Müller, R.H., Heinemann, S.,
PCS and zeta potential characterization of model particles and colloidal drug
carriers - essential information for the interpretation of cell culture
studies, Biochem. Soc. Trans. 19, 1991
(64) Lucks, J.S., Müller, B.W., Müller, R.H.,
Influence of sterically stabilizing agents on the stability of fat emulsions,
J. Pharm. Pharmacol. Suppl., 137p, 1991
(65) Diederichs, J.E., Weyhers, H., Müller, R.H.,
Microviscosity of egg lecithin films in Lipofundin fat emulsions, Arch. Pharm.
324, 692, 1991
(66) Müller, R.H., Lucks, J.S., Herbort, J., Couvreur, P.,
Improved treatment of liver metastasis by titanocene dichloride using an
emulsion carrier, Arch. Pharm. 324, 693, 1991
(67) Müller, R.H., Heinemann, S.,
Stability of TPN-regimens based on Lipofundin / Intralipid containing a high
electrolyte load, Arch. Pharm. 324, 694, 1991
(68) Blunk, T., Hochstrasser, D.F., Rudt, S., Müller, R.H.,
Two-dimensional electrophoresis in the concept of differential opsonization -
an approach to drug targeting, Arch. Pharm. 324, 706, 1991
(69) Müller, R.H., Rudt, S., Increased
sensitivity of the chemiluminescence assay for phagocytosis by optimized
analytical parameters, Arch. Pharm. 324, 714, 1991
(70) Diederichs, J.E., Müller, R.H.,
Determination of the microviscosity of surfactant films and phospholipid
layers, Arch. Pharm. 324, 607, 1991
(71) Fjellestad, A.G., Lucks, J.S., Waaler, T., Müller,
B.W., Müller, R.H., Measurement of interfacial tensions as a tool to
optimize the development of emulsions as intravenous drug carrier systems,
Arch. Pharm. 324, 640, 1991
(72) Müller, R.H.,
Characterization of Nanoparticles, Fat Emulsions and Inorganic Suspensions by Zetapotential
Measurements, Malvern Instruments Zetapotential-Workshop, Budapest, 28.1.1992
(73) Lucks, J.S., Müller, B.W., Diederichs, J.E., Müller,
R.H., Effect of minor components on emulsion stability
investigated by mixture model design, Eur. J. Pharm. Biopharm. 38,
10S, 1992
(74) Müller, R.H., Bräuer, A., Cytotoxicity
of cyanoacrylate nanoparticles in hepatocyte culture determined by cellular LDH
and potassium release, Eur. J. Pharm. Biopharm. 38, 14S, 1992
(75) Blunk, T., Hochstrasser, D.F., Müller, R.H.,
Plasma component adsorption patterns on colloidal drug carriers - determination
by two-dimensional electrophoresis, Eur. J. Pharm. Biopharm. 38,
32S, 1992
(76) Maaßen, S., Müller, R.H., Assessment
of cytotoxicity by chemiluminescence assay of the phagocytic activity, Eur. J.
Pharm. Biopharm. 38, 32S, 1992
(77) Diederichs, J.E., Mehnert, W., Lucks, J.S., Müller,
R.H., DSC investigations of parenteral fat emulsions, Eur.
J. Pharm. Biopharm. 38, 32S, 1992
(78) Lucks, J.S., Müller, R.H., König, B.,
Solid lipid nanoparticles (SLN) - an alternative parenteral drug delivery
system, Eur. J. Pharm. Biopharm. 38, 33S, 1992
(79) Lukowski, G., Müller, R.H., Müller, B.W., Dittgen, M.,
Surface characterization of acrylic acid copolymer nanoparticles for drug
delivery, Eur. J. Pharm. Biopharm. 38, 41S, 1992
(80) Bock, T.K., Müller, R.H., Müller, B.W., A
new test for determining the hemolytic activity of drugs incorporated in
colloidal carriers, Eur. J. Pharm. Biopharm. 38, 42S, 1992
(81) Schuhmann, R., Mehnert, W., Müller R.H., Coalescence kinetics of fat emulsions determined by Coulter counter measurements, Eur. J. Pharm. Biopharm. 38, 43S, 1992
(82) Blunk, T., Hochstrasser, D.F., Sanchez, J.-C., Müller, B.W., Müller, R.H., Plasmaprotein-Adsorptionsmuster auf kolloidalen Arzneistoffträgern - eine neue Perspektive im Drug Targeting, Arch. Pharm 326, 613, 1993
(83) Diederichs, J.E., Müller, R.H., Surfactant-Liposomen zur Behandlung des IRDS - Scaling up der Herstellung, Arch. Pharm 326, 626, 1993
(84) Schuhmann, R., Müller, R.H., Koaleszenzverhalten von Emulsionen in Abhängigkeit von Elektrolytkonzentration, Temperatur und Konzentration der dispersen Phase, Arch. Pharm 326, 732, 1993
(85) Blunk, T., Hochstrasser, D.F., Sanchez, J.-C., Calvör, A., Lück, M., Müller, B.W., Müller, R.H., Zweidimensionale Gelelektrophorese zur Untersuchung der Plasmaproteinadsorption auf Nanopartikeln, Arch. Pharm 326, 751, 1993
(86) zur Mühlen, A., Schwarz, C., Mehnert, W., Müller, R.H., Produktion von "solid lipid nanoparticles" (SLN) für die kontrollierte Arzneistoffapplikation, Arch. Pharm 326, 752, 1993
(87) Diederichs, J.E., Müller, R.H., Reifung und Mikroviskosität von
Surfactant-Liposomen zur Behandlung des IRDS, Arch. Pharm 326,
755, 1993
(88) Blunk, T., Hochstrasser, D.F., Sanchez, J., Müller,
B.W., Müller, R.H., Different protein adsorption patterns on i.v. drug
carriers targeted to bone marrow and circulating in blood, Eur. J. Pharm. Biopharm.
40, 33S, 1994
(89) Diederichs, J.E., Müller, R.H.,
Large-scale production of liposomes for IRDS treatment - effect of production
parameters on liposome quality, Eur. J. Pharm. Biopharm. 40,
25S, 1994
(90) Schwarz, C., Mehnert, W., Müller, R.H.,
Influence of production parameters of solid lipid nanoparticles (SLN) on the
suitability for intravenous injection, Eur. J. Pharm. Biopharm. 40,
24S, 1994
(91) Weyhers, H., Mehnert, W., Müller, R.H.,
Production and characterization of surface-modified "solid lipid
nanoparticles" (SLN), Eur. J. Pharm. Biopharm. 40,
15S, 1994
(92) Huber, G.M.W., Müller, R.H., Becker, R.,
Prediction of the flow properties of mixtures of bulk solids using a model
equation based on the powder characteristics, Eur. J. Pharm. Biopharm.
40, 20S, 1994
(93) Freitas, C., Mehnert, W., Müller, R.H.,
Stabilization of "solid lipid nanoparticles" (SLN) by spray drying,
Eur. J. Pharm. Biopharm. 40, 29S, 1994
(94) Maaßen, S., Weyhers, H., Mehnert, W., Müller, R.H.,
Surface-modified solid lipid nanoparticles (SLN) - in vitro affinity to human
granulocytes, Eur. J. Pharm. Biopharm. 40, 41S, 1994
(95) Bucke, W.E., Hänsch, H., Ehlers, S., Müller, R.H.,
Production of liposomes with incorporated antimicrobials for treatment of M.
avium and M. tuberculosis infections, Eur. J. Pharm. Biopharm. 40,
42S, 1994
(96) Schwarz, C., Mehnert, W., Müller, R.H.,
Influence of drug incorporation and lyophilisation on the physical stability of
solid nanoparticles (SLN), Eur. J. Pharm. Biopharm. 40,
52S, 1994
(97) Radatz, C., Sachse, A., Rößling, G., Müller, R.H.,
Stabilization of iopromide-carrying liposomes by freeze drying. Influence of
freezing and lyophilization conditions on the quality of the resuspended
material, Eur. J. Pharm. Biopharm. 40, 53S, 1994
(98) Schuhmann, R., Müller, R.H.,
Determination of stabilizing and destabilizing effects in TPN-regimes, Eur. J.
Pharm. Biopharm. 40, 54S, 1994
(99) Rühl, D., Maaßen, S., Schwarz, C., Mehnert, W., Müller, R.H., Comparative cytotoxicity of solid lipid nanoparticles (SLN), polyester and cyanoacrylate particles, Eur. J. Pharm. Biopharm. 40, 61S, 1994
(100) Schuhmann, R., Müller, R.H., Problemstellungen und Lösungsmöglichkeiten bei der Probenaufbereitung für den Coulter counter, Coulter User-Meeting, Krefeld, 27. Januar 1994
(101) Schuhmann, R., Müller, R.H., Stabilitätsuntersuchungen von pharmazeutischen Produkten mit dem Coulter-Meßprinzip, Coulter User-Meeting, Krefeld, 27. Januar 1994
(102) Schuhmann, R., Müller, R.H., Stabilitätsuntersuchungen von
pharmazeutischen Produkten, insbesondere von TPN-Regimen, mit dem Coulter
Meßprinzip, Coulter Workshop, Bayer AG, Leverkusen, 9. Februar 1994
(103) Müller, R.H., Drug targeting with intravenously injected nanoparticles, 1st International Meeting on Pharmacy & Pharmaceutical Sciences, Istanbul, 4.-7. September, 22, 1994
(104) Bucke, W.E., Hänsch, H.C.R., Ehlers,
S., Diederichs, J.E., Müller, R.H., Hahn, H., Liposome-encapsulated amikacin. I.
Production and characterization, Conference on Liposomes in Biomedical
Research, Max-Delbrück-Centrum, Berlin, Oktober 1994
(105) Ehlers, S., Hänsch, H.C.R.,
Bucke, W., Müller, R.H., Hahn, H.,
Liposome-encapsulated amikacin. II. Therapeutic efficacy in
experimental infection with Mycobacterium avium, Conference on Liposomes
in Biomedical Research, Max-Delbrück-Centrum, Berlin, Oktober 1994
(106) Diederichs,
J.E., Müller, R.H., Industrial Scale Production and Characterisation of
Lung Surfactant Liposomes, Conference on Liposomes in Biomedical Research,
Max-Delbrück-Centrum, Berlin, Oktober 1994
(107) Hänsch,
H.C.R., Bucke, W., Müller, R.H., Hahn, H., Mielke, M.E.A., Ehlers, S., Mechanism
of granuloma formation (GF) during experimental infection with Mycobacterium
avium, 12th European Immunology Meeting, European Federation of
Immunological Society, Barcelona, Abstr. no. 7, 379,
June 1994
(108) Müller,
R.H., Blunk, T., Lück. M., Drug targeting
with intravenously injectable nanoparticles - surface modification by polymer
adsorption and interaction with plasma proteins, 5th Symposium on Surface and
Colloid Science - Workshop on Amphiphilic Polymers, University of Lund, 19th
- 20th October 1994
(109) Müller, R.H.,
Blunk, T., Lück, M., Hochstrasser, D.F., Sanchez, J.-C., Müller B.W.,
Protein Adsorption on a Range of Surface-Modified Polystyrene Particles -
Evaluation by HR Two- Dimensional Polyacrylamide Gel Electrophoresis, Eur. J.
Pharm. Sci. 2, 92, 1994
(110) Schwarz, C.,
Mehnert, M., Müller, R.H., Lyophilization of Solid Lipid Nanoparticles (SLN),
Eur. J. Pharm. Sci. 2, 177, 1994
(111) Freitas, C.,
Lucks, J.S., Müller, R.H., Effect of Storage Conditions on Long-Term Stability
of "Solid Lipid Nanoparticles" (SLN) in Aqueous Dispersion, Eur. J.
Pharm. Sci. 2, 178, 1994
(112) Schuhmann, R.
Müller R.H., Physical Long Term Stability of Lipofundin Fat
Emulsions for Parenteral Nutrition, Eur. J. Pharm. Sci. 2, 186,
1994
(113) Huber, G.M.W.,
Müller, R.H., Becker, R., Prediction of the Flow Properties of Mixtures of
Bulk Solids Using Model Equations Based on the Specific Surface and the
Jenike-Flow Factor, Eur. J. Pharm. Sci. 2, 190, 1994
(114) Rühl, D.,
Schulze-Forster, K., Maurer, H.R., Müller, R.H., Poloxamer and
Poloxamine Surface-Modified Polystyrene Model Drug Carriers: Interaction with
HL 60 Cells, Eur. J. Pharm. Sci. 2, 192, 1994
(115) Blunk, T.,
Lück, M., Hochstrasser, D.F., Sanchez, J.-C., Müller B.W., Müller, R.H., Kinetics
of Protein Adsorption on Model Particles for Drug Targeting, Eur. J. Pharm. Sci.
2, 192, 1994
(116) Bucke, W.E.,
Hänsch, H.C.R., Ehlers, S., Diederichs, J.E., Müller, R.H., Hahn, H.,
Amikacin-Loaded Liposomes - Production, Characterization and Treatment
Efficiency in Mycobacterium Avium Intracellulare Complex (MAC) Infected Mice,
Eur. J. Pharm. Sci. 2, 176, 1994
(117) Weyhers, H.,
Lück, M., Mehnert, W., Müller, R.H., Solid Lipid
Nanoparticles (SLN) for Controlled Delivery of Hydrophilic Drugs, 2nd
International Conference on Biotechnology, Ghent, Belgium, April 1995
(118) Lück, M.,
Blunk, T., Paulke B.-R., Müller, R.H., Plasma
Protein Adsorption Patterns on Latex Particles with Different Surface Groups -
Evaluation by Two-Dimensional Polyacrylamide Gel Electrophoresis, 2nd
International Conference on Biotechnology, Ghent, Belgium, April 1995
(119) Weyhers,
H., Ehlers. S., Mehnert, W., Hahn, H., Müller, R.H., In
Vivo Toxicity of Cetylpalmitate and Compritol ATO 88 SLN, Poster presentation
at the 1st Expert Meeting on Colloidal Drug Carriers, Berlin, 15.-17. Juni
1995, Poster Nr.: 2
(120) Haltner, E.,
Weyhers, H., Mehnert, W., Müller, R.H., Lehr, C.M., Interactions
of SLN with Caco-2 cell-monolayers, Poster presentation at the 1st Expert
Meeting on Colloidal Drug Carriers, Berlin, 15.-17. Juni 1995,
Poster Nr.: 3
(121) Freitas, C.,
Lucks, J.S., Müller, R.H., Investigation of Long-Term Stability of SLN in Aqueous
Dispersion, Poster presentation at the 1st Expert Meeting on Colloidal Drug
Carriers, Berlin, 15.-17. Juni 1995, Poster Nr.: 6
(122) Blunk, T.,
Lück, M., Müller B.W., Müller, R.H., Interaction
between Plasma Proteins and Nanoparticles Coated with Poloxamer 235, 238 and
407, Poster presentation at the 1st Expert Meeting on Colloidal Drug Carriers, Berlin,
15.-17. Juni 1995, Poster Nr.: 20